Analysis of serum undercarboxylated osteocalcin level in rats with type 2 diabetes mellitus and the correlation with cognitive impairment
| Autor: | Jing Su, Feng Yu, Qian Yang, Yan Chen, Shi-Lian Hu, Peng-Ying Gu, Song Jin, Liang Zhao |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty type 2 diabetes mellitus medicine.medical_treatment Intraperitoneal injection Blood lipids Morris water navigation task 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immunology and Microbiology (miscellaneous) Internal medicine medicine Adiponectin Triglyceride business.industry Insulin Type 2 Diabetes Mellitus Sprague-Dawley rats General Medicine Articles 030104 developmental biology Endocrinology undercarboxylated osteocalcin chemistry cognitive disorders business 030217 neurology & neurosurgery Lipoprotein |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-0981 |
| Popis: | The aim of the study was to investigate the correlation between the serum undercarboxylated osteocalcin (ucOC) level and the blood biochemistry and cognitive impairment in rats with type 2 diabetes mellitus (T2DM). Sprague-Dawley (SD) rats were randomly divided into the normal control group (NC) and type 2 DM group. DM group received the high-fat and high-sugar diet combined with the intraperitoneal injection of low-dose STZ to establish the type 2 DM rat model. After 12 weeks of feeding, a Morris water maze was used to observe the rats' cognitive ability, and the levels of blood lipid, ucOC, insulin and adiponectin in the two groups were measured. The results showed that blood glucose of rats in DM group was increased significantly at 2-12 weeks (p |
| Databáze: | OpenAIRE |
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