Results of a real-world study on vortioxetine in patients with major depressive disorder in South East Asia (REVIDA)
| Autor: | Boon Beng David Yeoh, Lars Nelleman, Ashwini Nayak, Solaphat Hemrungrojn, Koon Choong Au Yong, Azhar Zain, Chalowat Inpa, Liam Kai Tay, Calvin Fones, Marvin Swee Woon Chong, Lionel Chee-Chong Lim, Eng Khean Ung, Chin Hong Yap, Teck Hoe Yen, Carmina Bernardo, Cheuk Ngen Chin, Patanon Kwansanit |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty 03 medical and health sciences 0302 clinical medicine Cognition Activities of Daily Living Medicine Humans In patient South east asia South east asian Psychiatry Depression (differential diagnoses) Asia Southeastern Work Performance Vortioxetine Psychiatric Status Rating Scales Depressive Disorder Major business.industry Depression General Medicine Middle Aged medicine.disease Antidepressive Agents 030227 psychiatry Treatment Outcome Major depressive disorder Antidepressant Female business 030217 neurology & neurosurgery |
| Zdroj: | Current medical research and opinion. 34(11) |
| ISSN: | 1473-4877 |
| Popis: | Objective: The REVIDA study aimed to assess the evolution of major depression symptoms in South East Asian (SEA) patients treated with vortioxetine for major depression in real-world clinical practice. Methods: This non-interventional study was conducted from August 2016 to April 2017. A total of 138 patients (aged 18–65 years) with an active episode of major depression were recruited from Malaysia, Philippines, Singapore and Thailand. Vortioxetine was initiated on the first visit and patients were followed for 3 months. Depression severity was assessed using the PHQ-9 questionnaire (patient assessed) and CGI-S scale (physician assessed); cognitive function was assessed with the PDQ-D questionnaire; work productivity and activity impairment (WPAI) was assessed with the WPAI questionnaire. Results: At baseline, 89.9% of patients were moderately to severely depressed (PHQ-9 score ≥10). During the 3 month treatment period, mean ± SD PHQ-9 score decreased from 18.7 ± 5.7 to 5.0 ± 5.3, mean ± SD CGI-S score decreased from 4.4 ± 0.7 to 2.2 ± 1.1 and mean ± SD PDQ-D score decreased from 42.1 ± 18.8 to 13.4 ± 13.0. By Month 3, response and remission rates reached 80.8% and 59.0%, respectively. Work productivity loss decreased from 73.6% to 30.5%, while activity impairment decreased from 71.5% to 24.6%. Positive correlations were observed between PHQ-9, PDQ-D, and WPAI work productivity loss and activity impairment. By Month 3, 82.0% of patients were either not depressed or only mildly depressed (PHQ-9 score ≤9). Conclusion: In real-world clinical settings, vortioxetine was effective in reducing depression severity and improving cognitive function and work productivity in SEA patients with major depression. |
| Databáze: | OpenAIRE |
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