Synergizing Upconversion Nanophotosensitizers with Hyperbaric Oxygen to Remodel the Extracellular Matrix for Enhanced Photodynamic Cancer Therapy
| Autor: | Jinzhao Huang, Jingqiu Li, Lingtao Zhu, Yanhong Zhu, Yanxiao Ao, Yu Miao, Zhongzheng Yu, Xiangliang Yang, Shiyu Li, Yan Zhang, Xiaoli Lan |
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| Rok vydání: | 2018 |
| Předmět: |
Materials science
medicine.medical_treatment Cancer therapy Photodynamic therapy 02 engineering and technology 010402 general chemistry 01 natural sciences Models Biological Extracellular matrix Mice Hyperbaric oxygen medicine Tumor Microenvironment Animals General Materials Science Therapeutic strategy chemistry.chemical_classification Reactive oxygen species Hyperbaric Oxygenation Mice Inbred BALB C Photosensitizing Agents 021001 nanoscience & nanotechnology Xenograft Model Antitumor Assays Photon upconversion 0104 chemical sciences Extracellular Matrix chemistry Photochemotherapy Cancer cell Cancer research Nanoparticles Female 0210 nano-technology Reactive Oxygen Species |
| Zdroj: | ACS applied materialsinterfaces. 10(27) |
| ISSN: | 1944-8252 |
| Popis: | Photodynamic therapy (PDT) holds great promise as a noninvasive and selective cancer therapeutic treatment in preclinical research and clinical practice; however, it has limited efficacy in the ablation of deep-seated tumor because of hypoxia-associated circumstance and poor penetration of photosensitizers to cancer cells away from the blood vessels. To tackle the obstacles, we propose a therapeutic strategy that synergizes upconversion nanophotosensitizers (UNPSs) with hyperbaric oxygen (HBO) to remodel the extracellular matrix for enhanced photodynamic cancer therapy. The UNPSs are designed to have an Nd3+-sensitized sandwiched structure, wherein the upconversion core serves as light transducers to transfer energy to the neighboring photosensitizers to produce reactive oxygen species (ROS). With HBO, photodynamic process can generate abundant ROS in the intrinsically hypoxic tumor. It is revealed for the first time that HBO-assisted PDT decomposes collagen in the extracellular matrix of tumor and thus f... |
| Databáze: | OpenAIRE |
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