Rabies virus diversification in aerial and terrestrial mammals
| Autor: | Carla Isabel Macedo, Caio César de Melo Freire, Sabri Saeed Sanabani, Paulo Eduardo Brandão, Pedro Carnieli, Sibele Pinheiro de Souza, Juliana Galera Castilho, Jaqueline T. Watanabe, Rodrigo Pessôa, Atila Iamarino, Rafael de Novaes Oliveira, Paolo Marinho de Andrade Zanotto, Helena Beatriz de Carvalho Ruthner Batista |
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| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
0301 basic medicine Most recent common ancestor Evolutionary Genetics heterotachy QH426-470 medicine.disease_cause phylogeny 01 natural sciences Heterotachy 03 medical and health sciences medicine Genetics Rabies transmission Molecular Biology Lyssavirus genome Phylogenetic tree biology molecular evolution Rabies virus NUCLEOTÍDEOS biology.organism_classification medicine.disease 030104 developmental biology Evolutionary biology Sylvatic cycle Rabies 010606 plant biology & botany |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Genetics and Molecular Biology, Volume: 43, Issue: 3, Article number: e20190370, Published: 31 JUL 2020 Genetics and Molecular Biology, Vol 43, Iss 3 (2020) Genetics and Molecular Biology Genetics and Molecular Biology v.43 n.3 2020 Sociedade Brasileira de Genética (SBG) instacron:SBG |
| Popis: | Rabies is a fatal zoonotic infection of the central nervous system of mammals and has been known to humans for millennia. The etiological agent, is a neurotropic RNA virus in the order Mononegavirales, family Rhabdoviridae, genus Lyssavirus. There are currently accepted to be two cycles for rabies transmission: the urban cycle and the sylvatic cycle. The fact that both cycles originated from a common RABV or lyssavirus ancestor and the adaptive divergence that occurred since then as this ancestor virus adapted to a wide range of fitness landscapes represented by reservoir species in the orders Carnivora and Chiroptera led to the emergence of the diverse RABV lineages currently found in the sylvatic and urban cycles. Here we study full genome phylogenies and the time to the most recent common ancestor (TMRCA) of the RABVs in the sylvatic and urban cycles. Results show that there were differences between the nucleotide substitution rates per site per year for the same RABV genes maintained independently in the urban and sylvatic cycles. The results identify the most suitable gene for phylogenetic analysis, heterotachy among RABV genes and the TMRCA for the two cycles. |
| Databáze: | OpenAIRE |
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