D-Cycloserine, a partial NMDA recepto r-associated glycine-B site agonist, enhances reversal learning, but a cholinesterase inhibitor and nicotine has no effect
| Autor: | Sami Ikonen, Minna Riekkinen, Paavo Riekkinen |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Agonist
Nicotine Antimetabolites medicine.drug_class Glycine D-cycloserine Reversal Learning Stimulation Water maze Pharmacology Receptors N-Methyl-D-Aspartate Partial agonist Alzheimer Disease Conditioning Psychological medicine Animals Nicotinic Agonists Rats Wistar Maze Learning Cholinesterase Binding Sites biology Chemistry General Neuroscience Denervation Rats Cycloserine Tacrine biology.protein NMDA receptor Septal Nuclei Cholinesterase Inhibitors medicine.drug |
| Zdroj: | NeuroReport. 9:3647-3651 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/00001756-199811160-00016 |
| Popis: | The present study examined the efficacy of single and combined treatments with an anticholinesterase, tetrahydroaminoacridine, nicotine and a glycine-B site partial agonist, D-cycloserine, in alleviating the water maze reversal learning defect induced by a medial septal lesion. D-cycloserine (3 and 10 mg/kg) improved reversal learning. Tetrahydroaminoacridine (1 and 3 mg/kg) and nicotine (0.1 and 0.3 mg/kg) had no effect on reversal learning. A combination of tetrahydroaminoacridine 3 mg/kg or nicotine 0.3 mg/kg and D-cycloserine 10 mg/kg was not more effective than D-cycloserine 10 mg/kg alone in improving reversal learning. This suggests that stimulation of NMDA mechanisms may more effectively improve in medial septal-lesioned rats reversal learning processes than stimulation of cholinergic activity. |
| Databáze: | OpenAIRE |
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