Aza- and Azo-Stilbenes: Bio-Isosteric Analogs of Resveratrol
| Autor: | Dominique Vervandier-Fasseur, Norbert Latruffe, Gérard Lizard |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pterostilbene
Research groups Pharmaceutical Science Review Resveratrol Stilbenoid Antioxidants Analytical Chemistry lcsh:QD241-441 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine lcsh:Organic chemistry Drug Discovery Stilbenes Physical and Theoretical Chemistry azo-stilbene 030304 developmental biology Piceatannol 0303 health sciences Aza Compounds Molecular Structure structure-activity relationship Organic Chemistry food and beverages Stereoisomerism bio-isosterism trans-resveratrol Combinatorial chemistry aza-stilbene chemistry Chemistry (miscellaneous) Polyphenol 030220 oncology & carcinogenesis Molecular Medicine Azo Compounds |
| Zdroj: | Molecules Molecules, Vol 25, Iss 3, p 605 (2020) |
| ISSN: | 1420-3049 |
| Popis: | Several series of natural polyphenols are described for their biological and therapeutic potential. Natural stilbenoid polyphenols, such as trans-resveratrol, pterostilbene and piceatannol are well-known for their numerous biological activities. However, their moderate bio-availabilities, especially for trans-resveratrol, prompted numerous research groups to investigate innovative and relevant synthetic resveratrol derivatives. This review is focused on isosteric resveratrol analogs aza-stilbenes and azo-stilbenes in which the C=C bond between both aromatic rings was replaced with C=N or N=N bonds, respectively. In each series, synthetic ways will be displayed, and structural sights will be highlighted and compared with those of resveratrol. The biological activities of some of these molecules will be presented as well as their potential therapeutic applications. In some cases, structure-activity relationships will be discussed. |
| Databáze: | OpenAIRE |
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