Metabolism Plays a Key Role during Macrophage Activation
| Autor: | Stoyan Ivanov, Marion I. Stunault, Gael Bories, Rodolphe Guinamard |
|---|---|
| Přispěvatelé: | Centre méditerranéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
[SDV]Life Sciences [q-bio] Immunology Inflammation Review Article Carbohydrate metabolism 03 medical and health sciences Immune system Phagocytosis lcsh:Pathology medicine Animals Humans Macrophage Amino Acids Efferocytosis ComputingMilieux_MISCELLANEOUS Tissue homeostasis Chemistry Macrophages Monocyte Fatty Acids Cell Biology Macrophage Activation Cell biology Metabolic pathway Glucose 030104 developmental biology medicine.anatomical_structure medicine.symptom lcsh:RB1-214 |
| Zdroj: | Mediators of Inflammation Mediators of Inflammation, Hindawi Publishing Corporation, 2018, 2018, pp.1-10. ⟨10.1155/2018/2426138⟩ Mediators of Inflammation, Vol 2018 (2018) |
| ISSN: | 1466-1861 0962-9351 |
| Popis: | Monocyte and macrophage diversity is evidenced by the modulation of cell surface markers and differential production of soluble mediators. These immune cells play key roles in controlling tissue homeostasis, infections, and excessive inflammation. Macrophages remove dead cells in a process named efferocytosis, contributing to the healthy tissue maintenance. Recently, it became clear that the main macrophage functions are under metabolic control. Modulation of glucose, fatty acid, and amino acid metabolism is associated with various macrophage activations in response to external stimuli. Deciphering these metabolic pathways provided critical information about macrophage functions. |
| Databáze: | OpenAIRE |
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