Psychological stress effects on myelin degradation in the cuprizone-induced model of demyelination
| Autor: | Ali Akbar Saboury, Saeed Karima, Amirbahador Zeynali, Gholam Hossein Riazi, Monireh-Sadat Mousavi, Shahin Ahmadian, Pouya Sharif Dashti, Sogol Meknatkhah |
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| Přispěvatelé: | Meknatkhah, S, Sharif Dashti, P, Mousavi, M, Zeynali, A, Ahmadian, S, Karima, S, Saboury, A, Riazi, G |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty psychological stre Disease Luxol fast blue stain Corpus Callosum Pathology and Forensic Medicine Cuprizone 03 medical and health sciences Myelin 0302 clinical medicine Demyelinating disease medicine Animals Rats Wistar Myelin Sheath biology business.industry Multiple sclerosis General Medicine medicine.disease physical stre Myelin basic protein Staining Disease Models Animal 030104 developmental biology medicine.anatomical_structure cuprizone model multiple sclerosi biology.protein Immunohistochemistry Female demyelination Neurology (clinical) business Stress Psychological 030217 neurology & neurosurgery Demyelinating Diseases |
| Popis: | Multiple sclerosis (MS) is known as the most common demyelinating disease worldwide in which previous studies have shown that stress is a risk factor for the disease's onset and progression. Nevertheless, further studies are needed to investigate the consequences of stress in MS pathology. In this study, after 5 days of exposure to psychological and physical stress as a repetitive distress modality, rats were treated with cuprizone. The demyelination degree was compared in animal groups using Luxol fast blue staining, immunohistochemical staining for myelin basic protein and transmission electron microscopy. Outcomes revealed that animals exposed to stress prior to cuprizone ingestion, elicit more intense demyelination. Continuous psychological distress has more severe effects on myelin sheath destruction in the preclinical stage. |
| Databáze: | OpenAIRE |
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