Proangiogenic signature in advanced laryngeal carcinoma after microRNA expression profiling
| Autor: | V.Y. Petkova, Radka Kaneva, T. Popov, S. Giragosyan, Ts. Marinov, J. Rangachev, Gergana Stancheva, D. Popova, M. Belitova |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Tumor angiogenesis Male Microarray Angiogenesis Total rna Gene Expression 03 medical and health sciences 0302 clinical medicine microRNA Genetics Carcinoma medicine Biomarkers Tumor Humans Molecular Biology Laryngeal Neoplasms Aged Neovascularization Pathologic business.industry Gene Expression Profiling General Medicine Middle Aged medicine.disease Microarray Analysis Tumor tissue Gene expression profiling Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology 030220 oncology & carcinogenesis Cancer research Female business Transcriptome |
| Zdroj: | Molecular biology reports. 47(7) |
| ISSN: | 1573-4978 |
| Popis: | The aim of this study is to evaluate which dysregulated angiomiRs compose the specific proangiogenic microRNA signature of advanced laryngeal cancer and review the literature. Thirty-six samples from twelve patients with advanced laryngeal carcinoma were collected. Total RNA was extracted and microRNA global profiling was performed using Agilent Technologies Microarray Kit. Fifty-nine microRNAs were found to have significantly different expression levels. Eleven microRNAs from the whole group were sorted as regulators of tumor angiogenesis (angiomiRs): seven were up-regulated-miR-1246, miR-181b 5p, miR-18a 5p, miR-21 3p, miR-210 3p, miR-503 5p, miR-93 5p and four were down-regulated-miR148a 5p, miR-145 5p, miR-204 5p, miR-125b 5p. For none of those microRNAs we found heterogeneity in tumor tissue. We are the first to report the specific proangiogenic microRNA signature in advanced laryngeal carcinoma and we confirm and amplify findings from previous studies that expand our perception of a specific "molecular state" of angiogenesis that is distinctive only for laryngeal cancer. |
| Databáze: | OpenAIRE |
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