Anxiolytic‐Like Action of Selected 4‐(Alkylamino)‐3‐nitrocoumarin Derivatives in BALB/c Mice
| Autor: | Sonja Ilić, Vidoslav Dekić, Pavle J. Randjelović, Biljana Dekić, Niko S. Radulović, Nikola Stojanovic, Nenad Stojiljković |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Substituent Bioengineering Gastrointestinal pathogens Anxiety Pharmacology 01 natural sciences Biochemistry Anxiolytic like BALB/c Mice chemistry.chemical_compound 3-nitrocoumarin Coumarins Animals Molecular Biology Mice Inbred BALB C Diazepam Behavior Animal biology Antianxiety Agent 010405 organic chemistry Chemistry General Chemistry General Medicine biology.organism_classification Coumarin 0104 chemical sciences 010404 medicinal & biomolecular chemistry Anti-Anxiety Agents Sedative Effects Molecular Medicine Sleep |
| Zdroj: | Chemistry & Biodiversity. 17 |
| ISSN: | 1612-1880 1612-1872 |
| Popis: | In this work, we explored the possible polypharmacological potential of the already established antimicrobials against gastrointestinal pathogens, 4-(alkylamino)-3-nitrocoumarins, as antianxiety agents, using a battery of in vivo experiments. Three chosen coumarin derivatives, differing in the substituent (sec-butylamino, hexadecylamino, or benzylamino) at position 4, at the doses of 25, 50 and 100 mg kg-1 , were evaluated in light/dark, open-field, horizontal wire and diazepam-induced sleep models using male BALB/c mice. Depending on the applied dose, all three tested coumarins displayed a noteworthy anxiolytic-like effect. 4-(sec-Butylamino)-3-nitro-2H-chromen-2-one and 4-(hexadecylamino)-3-nitro-2H-chromen-2-one could be recognized as true anxiolytics in the lowest applied dose, based on three tests, without exerting any sedative effects. Thus, the 3-nitrocoumarin core deserves further chemical diversity exploration in the 'antianxiety' direction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text