Inhibition of adenylate cyclase by tetraplatin
| Autor: | B. T. Ho, Y. Y. Huo, Jong-Ho Lee, V. A. Levin |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Cancer Research Organoplatinum Compounds Dopamine Adenylate kinase Antineoplastic Agents In Vitro Techniques Pharmacology Cyclase chemistry.chemical_compound Enzyme activator medicine Animals Pharmacology (medical) Cisplatin Forskolin biology Rats Inbred Strains Corpus Striatum Enzyme assay Rats Enzyme Activation Oncology chemistry Adenylyl Cyclase Inhibitors biology.protein medicine.drug |
| Zdroj: | Anti-Cancer Drugs. 2:267-268 |
| ISSN: | 0959-4973 |
| DOI: | 10.1097/00001813-199106000-00007 |
| Popis: | In the investigation of effects of platinum-containing compounds on dopamine (DA)-activated adenylate cyclase system, tetraplatin and cisplatin were found to suppress the increase of enzyme activity by various activators. However, tetraplatin was a much more potent inhibitor than cisplatin, with its I50 values being 1/25, 1/45, and 1/130 that of cisplatin in the presence of DA/Gpp(NH)p, NaF/AlCl3, and forskolin/Gpp(NH)p respectively. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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