Rapid systemic uptake of naloxone after intranasal administration in children
| Autor: | Staffan Eksborg, Stefan Lundeberg, Eva Olsson, Per-Arne Lönnqvist, Carl-Olav Stiller |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
business.industry Naloxone medicine.medical_treatment Narcotic Antagonists Opioid overdose Venous blood Nasal Sprays medicine.disease Anesthesiology and Pain Medicine Pharmacokinetics Nasal spray Competitive antagonist Anesthesia Pediatrics Perinatology and Child Health medicine Humans Nasal administration Drug Overdose business Child Administration Intranasal Pediatric population medicine.drug |
| Zdroj: | Paediatric anaesthesiaREFERENCES. 31(6) |
| ISSN: | 1460-9592 |
| Popis: | Background Naloxone has a high affinity for the µ-opioid receptor and acts as a competitive antagonist, thus reversing the effects of opioids. Naloxone is often administrated intravenously, but there is a growing interest in the intranasal route in treating patients with opioid overdose, and in reversing effects after therapeutic use of opioids. As administration is painless and no intravenous access is needed, the intranasal route is especially useful in children. Aim The aim of this study was to investigate the uptake of naloxone 0.4 mg/ml during the first 20 min after administration as a nasal spray in a pediatric population, with special focus on the time to achieve maximum plasma concentration. Methods Twenty children, 6 months-10 years, were included in the study. The naloxone dose administered was 20 µg/kg, maximum 0.4 mg, divided into repeated doses of 0.1 ml in each nostril. Venous blood samples were collected at 5, 10, and 20 min after the end of administration. Results All patients had quantifiable concentrations of naloxone in venous blood at 5 min, and within 20 min, peak concentration had been reached in more than half of the children. At 20 min after intranasal administration, the plasma naloxone concentrations were within the range of 2-6 nanogram/ml. Conclusion This study confirms the clinical experience that the rapid effect of naloxone after intranasal administration in children was reflected in rapid systemic uptake to achieve higher peak plasma concentrations than previously reported in adults. |
| Databáze: | OpenAIRE |
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