Identification of glabridin as a bioactive compound in licorice (Glycyrrhiza glabra L.) extract that activates human peroxisome proliferator-activated receptor gamma (PPARγ)
| Autor: | Kelly M. Glynn, Stephen R. Missler, John F. Rebhun |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Peroxisome proliferator-activated receptor
CHO Cells Plant Roots chemistry.chemical_compound Cricetulus Phenols Drug Discovery medicine Glycyrrhiza Animals Humans Glycyrrhizin Receptor Pharmacology chemistry.chemical_classification biology Molecular Structure Plant Extracts Troglitazone General Medicine Hep G2 Cells Peroxisome biology.organism_classification Isoflavones Bioactive compound Up-Regulation PPAR gamma chemistry Biochemistry Gene Expression Regulation Glabridin medicine.drug |
| Zdroj: | Fitoterapia. 106 |
| ISSN: | 1873-6971 |
| Popis: | Licorice, the root and stolons of the Glycyrrhiza plant (Fabaceae), has been used for centuries as a food additive (sweetener), in cosmetics, and in traditional medicine. In this research, we provide evidence that licorice extract activates peroxisome proliferator-activated receptor gamma (PPARγ) and, as identified through HPLC fractionation and mass spectroscopy, one of the activating phytochemicals is glabridin. Glabridin was shown to bind to and activate PPARγ. It was also shown to activate PPARγ-regulated gene expression in human hepatoma cells similar to known PPARγ ligands and that the expression was blocked by a PPARγ specific antagonist. |
| Databáze: | OpenAIRE |
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