Biological and molecular basis of human breast cancer
| Autor: | Yun-Fu Hu, Xiaoqi Yang, Quivo Tahin, Bove Ba, Ismael Dale Cotrim Guerreiro da Silva, Yajue Huang, Jose Russo, Wu Y, Irma H. Russo, Abdel-Rahman N. Zekri, Higgy N |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Cell Survival
Cell Cell Culture Techniques Breast Neoplasms Biology Fatty Acid-Binding Proteins Genetic predisposition medicine Humans Neoplastic transformation Epigenetics Telomerase Cells Cultured Mechanism (biology) Chromosomes Human Pair 11 Cell Cycle Epithelial Cells Cell cycle Gene Expression Regulation Neoplastic Transformation (genetics) medicine.anatomical_structure Cell Transformation Neoplastic Microcell-mediated chromosome transfer Cancer research Female Carrier Proteins Fatty Acid Binding Protein 3 Chromosomes Human Pair 17 Microsatellite Repeats |
| Zdroj: | Frontiers in bioscience : a journal and virtual library. 3 |
| ISSN: | 1093-9946 |
| Popis: | Human breast cancer remains the most common malignancy in the American women. The ultimate cure of this disease relies on a better understanding of the mechanisms underlying the initiation and progression of this disease. The neoplastic transformation of HBEC in vitro represents a successful model for obtaining knowledge on the molecular and biological alterations that may contribute to the tumorigenic mechanisms. We have presented here a current understanding of chemically transformed HBEC in the following aspects: 1. Factors affecting the transformation of HBEC such as genetic predisposition and differentiation status and prior immortalization; 2. New targets for studying the mechanism of cell immortalization such as alterations in telomerase activity and differential expression of cell cycle dependent genes as well as others recently isolated through differential cloning such as H-ferritin, and a calcium binding protein; 3. Epigenetic and genetic mechanisms underlying cell transformation; 4. The association of microsatellite instability in specific loci on chromosomes 11, 13, and 16 with the progression of cell transformation; and 5. The application of microcell mediated chromosome transfer technique as an approach to testing the functional role of specific genes whose dysregulation or loss of function may contribute to the ultimate cell transformation. Further efforts in this cell system will be directed to determine the roles of identified molecular changes as well as the mapping/cloning of tumor suppressor or senescence genes such as those that may reside on chromosomes 11 or 17. |
| Databáze: | OpenAIRE |
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