Changes in Anesthetic Sensitivity and Glutamate Receptors in the Aging Canine Brain
| Autor: | Kathy R. Magnusson, Dunlop Ci, Ann E. Wagner, Chauna Scanga |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Aging medicine.medical_specialty Minimum alveolar concentration Glutamic Acid Hippocampal formation Tritium Hippocampus Receptors N-Methyl-D-Aspartate Dogs Internal medicine medicine Animals Receptors AMPA Receptor Cerebral Cortex Analysis of Variance Neurotransmitter Agents Dose-Response Relationship Drug Isoflurane business.industry Glutamate receptor Brain Dizocilpine Endocrinology Receptors Glutamate Anesthesia Anesthetics Inhalation Anesthetic NMDA receptor Female Dizocilpine Maleate Radiopharmaceuticals Geriatrics and Gerontology business Excitatory Amino Acid Antagonists medicine.drug |
| Zdroj: | The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 55:B448-B454 |
| ISSN: | 1758-535X 1079-5006 |
| DOI: | 10.1093/gerona/55.9.b448 |
| Popis: | This study investigated whether the aging process in dogs is associated with an increased sensitivity to inhalation anesthesia and whether age-related changes in glutamate receptors are related to the increased sensitivity. The mean minimum alveolar concentration (MAC) of isoflurane was 1.82 +/- .08% for 2-3 year olds and 1.45 +/- .06% for 11 years olds, indicating that there was an increased potency of isoflurane in the older dogs as compared to the young. These older animals also showed a significant decrease in binding of [3H]glutamate and [3H]dizocilpine ([3H]MK801) to N-methyl-D-aspartate (NMDA) receptors in multiple cortical and hippocampal regions. The density of binding to NMDA receptors in the cortex, using a single concentration of ligand, correlated significantly with individual MAC values. These results demonstrate that dogs experience an increase in anesthetic potency with increased age, similar to humans, and that age-related changes in the NMDA receptor may represent one mechanism underlying this increased sensitivity to anesthesia. |
| Databáze: | OpenAIRE |
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