Physical activity limits pulmonary endothelial activation in sickle cell SAD mice
| Autor: | Camille Faes, Aymen Romdhani, Vanessa Bourgeaux, Emmanuelle Charrin, Cyril Martin, Aymeric Douillard, Amine Bessaad, Geneviève De Souza, Emeline Aufradet, Erica N. Chirico, Vincent Pialoux, Emmanuelle Canet-Soulas |
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| Přispěvatelé: | Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Rok vydání: | 2014 |
| Předmět: |
Male
Erythrocytes Time Factors [SDV]Life Sciences [q-bio] Cell 030204 cardiovascular system & hematology Inbred C57BL Biochemistry chemistry.chemical_compound Mice 0302 clinical medicine hemic and lymphatic diseases Transgenes Lung ComputingMilieux_MISCELLANEOUS Abnormal/*metabolism Anemia Hematology Pathophysiology Hemolysis Physical Conditioning Cell Hypoxia 3. Good health Sickle Cell/metabolism/*physiopathology P-Selectin medicine.anatomical_structure P-Selectin/metabolism 030220 oncology & carcinogenesis medicine.symptom Vasculitis congenital hereditary and neonatal diseases and abnormalities Transgene Lung/*pathology Immunology Erythrocytes Abnormal Inflammation Endothelium/*metabolism Anemia Sickle Cell Biology Motor Activity Nitric oxide Endothelial activation 03 medical and health sciences Physical Conditioning Animal medicine Animals Humans Endothelium Vasculitis/*physiopathology Animal Cell Biology medicine.disease Mice Inbred C57BL chemistry |
| Zdroj: | Blood Blood, American Society of Hematology, 2014, 123 (17), pp.2745-7. ⟨10.1182/blood-2013-10-534982⟩ |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood-2013-10-534982⟩ |
| Popis: | To the editor: Vaso-occlusion (VOC) in sickle cell disease (SCD) results from many pathophysiological mechanisms including sickling of red blood cells, hemolysis, inflammation, vascular adhesion, and reduced nitric oxide (NO) bioavailability.[1][1] All these mechanisms interact together to trap |
| Databáze: | OpenAIRE |
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