Hypothalamic obesity, brown adipose tissue, and sympathoadrenal activity in rats
Autor: | J. G. Vander Tuig, Janos Kerner, Dale R. Romsos |
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Rok vydání: | 1985 |
Předmět: |
medicine.medical_specialty
Epinephrine Physiology Endocrinology Diabetes and Metabolism Adipose tissue Hypothalamus Middle Biology Hyperphagia Excretion chemistry.chemical_compound Norepinephrine Adipose Tissue Brown Physiology (medical) Internal medicine Brown adipose tissue Adrenal Glands medicine Sympathoadrenal system Animals Humans Obesity Neurotransmitter Myocardium Rats Inbred Strains Rats Endocrinology medicine.anatomical_structure chemistry Adipose Tissue Hypothalamus Female Energy Metabolism Thermogenesis medicine.drug Body Temperature Regulation |
Zdroj: | The American journal of physiology. 248(5 Pt 1) |
ISSN: | 0002-9513 |
Popis: | Obesity-producing, hypothalamic knife cuts and ventromedial hypothalamic (VMH) lesions in ad libitum-fed adult rats increased intake of a high-fat diet (123 and 130%) and energy retention (880 and 1,099%) during the 4-wk period postsurgery; even when pair fed to control rats, energy retention of the knife-cut and lesioned rats was still elevated (105 and 155%). Thermogenic capacity of brown adipose tissue (BAT), estimated from guanosine diphosphate (GDP) binding to BAT mitochondria, was unchanged in hyperphagic knife-cut and VMH-lesioned rats and was reduced approximately 50% when these rats were pair fed to controls. Urinary excretion of norepinephrine (NE) was approximately twofold higher in ad libitum-fed, knife-cut, and lesioned rats than in control rats; restriction of energy intake decreased NE excretion to control values. Rates of NE turnover in heart paralleled urinary NE excretion, whereas NE turnover in BAT was generally not increased in the hyperphagic rats. Urinary epinephrine excretion, an index of adrenal medullary activity, was depressed in all knife-cut and VMH-lesioned rats. Hyperphagia coupled with a lack of increased heat production in BAT causes gross obesity in ad libitum-fed, knife-cut, and VMH-lesioned rats, whereas obesity in pair-fed rats develops in part at least as a result of reduced heat production by BAT. |
Databáze: | OpenAIRE |
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