Effectiveness of Combining Plasma Exchange and Continuous Hemodiafiltration in Patients With Postoperative Liver Failure
| Autor: | Kimitaka Tajimi, Yoshihiro Asanuma, Chikara Yonekawa, Hajime Nakae |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Bilirubin medicine.medical_treatment Biomedical Engineering Urology Medicine (miscellaneous) Bioengineering Hemodiafiltration Citric Acid Biomaterials chemistry.chemical_compound Continuous hemodiafiltration medicine Hepatectomy Humans Effective treatment In patient Aged Plasma Exchange Interleukin-6 business.industry Interleukin-18 Liver failure General Medicine Liver Failure Acute Middle Aged Combined Modality Therapy Surgery Treatment Outcome chemistry Female Interleukin 18 business After treatment |
| Zdroj: | Artificial Organs. 29:324-328 |
| ISSN: | 1525-1594 0160-564X |
| DOI: | 10.1111/j.1525-1594.2005.29054.x |
| Popis: | Nine patients with postoperative liver failure were treated with plasma exchange (PE) or PE and continuous hemodiafiltration (CHDF), and various biochemical parameters were determined before and after treatment. Although citrate levels increased significantly after treatment compared with pretreatment levels in both the PE group and the PE + CHDF group (P < 0.0001 and P < 0.0001, respectively), the percentage of the increase in citrate levels was significantly higher in the PE group than in the PE + CHDF group (P = 0.0051). Total bilirubin (T-Bil) levels were significantly lower after treatment in both the PE and PE + CHDF groups (P < 0.0001 and P = 0.0001, respectively). There were no significant differences in T-Bil levels between the two groups (P = 0.5181). There were no significant differences in interleukin (IL)-6 levels before and after treatment in both the PE and PE + CHDF groups (P = 0.1281 and P = 0.2273, respectively). IL-18 levels were significantly lower after treatment in both the PE and PE + CHDF groups (P < 0.0001 and P = 0.0002, respectively), but there were no significant differences in the removal rate of IL-18 in both the PE and PE + CHDF groups (P = 0.8749). These results indicate that combining PE and CHDF in a series-parallel circuit is an effective modality for suppressing the elevation of blood citrate levels. This finding may have important implications for the development of an effective treatment for patients with postoperative liver failure. |
| Databáze: | OpenAIRE |
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