Perspectives on the mesenchymal origin of metastatic cancer
| Autor: | Leanne C. Huysentruyt, Thomas N. Seyfried |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Cancer Research
Myeloid Epithelial-Mesenchymal Transition Biomedicine general Cell Biology Non-Thematic Review Somatic evolution in cancer Metastasis 03 medical and health sciences 0302 clinical medicine Phagocytosis Neoplasms medicine Macrophage Animals Humans Epithelial–mesenchymal transition Myeloid/macrophage lineage Neoplasm Metastasis 030304 developmental biology 0303 health sciences Macrophages Mesenchymal stem cell Cancer Mesenchymal Stem Cells medicine.disease 3. Good health Biomedicine medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Immunology Epithelial–mesenchymal transitions Metastatic cancer |
| Zdroj: | Cancer Metastasis Reviews Huysentruyt, Leanne C.; & Seyfried, Thomas N.(2010). Perspectives on the mesenchymal origin of metastatic cancer. Cancer and Metastasis Reviews, 29(4), pp 695-707. doi: 10.1007/s10555-010-9254-z. Retrieved from: http://www.escholarship.org/uc/item/7wc625ws |
| ISSN: | 1573-7233 0167-7659 |
| Popis: | Emerging evidence suggests that many metastatic cancers arise from cells of the myeloid/macrophage lineage regardless of the primary tissue of origin. A myeloid origin of metastatic cancer stands apart from origins involving clonal evolution or epithelial–mesenchymal transitions. Evidence is reviewed demonstrating that numerous human cancers express multiple properties of macrophages including phagocytosis, fusogenicity, and gene/protein expression. It is unlikely that the macrophage properties expressed in metastatic cancers arise from sporadic random mutations in epithelial cells, but rather from damage to an already existing mesenchymal cell, e.g., a myeloid/macrophage-type cell. Such cells would naturally embody the capacity to express the multiple behaviors of metastatic cells. The view of metastasis as a myeloid/macrophage disease will impact future cancer research and anti-metastatic therapies. |
| Databáze: | OpenAIRE |
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