Arteriovenous differences of hematological and coagulation parameters in patients with sepsis
Autor: | Miroslav Durila, Sergej Jurčenko, Martina Pelichovská, Ivana Hadacova, Karel Cvachovec, Tomas Kalincik |
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Rok vydání: | 2010 |
Předmět: |
Adult
Male medicine.medical_specialty Fibrinogen Antithrombins Veins Sepsis Fibrin Fibrinogen Degradation Products Internal medicine D-dimer Medicine Humans Blood Coagulation Aged Aged 80 and over medicine.diagnostic_test business.industry Hematology General Medicine Venous blood Arteries Middle Aged medicine.disease Thromboelastography Surgery Thrombelastography Hemostasis Cardiology Arterial blood Female business Partial thromboplastin time medicine.drug |
Zdroj: | Blood coagulationfibrinolysis : an international journal in haemostasis and thrombosis. 21(8) |
ISSN: | 1473-5733 |
Popis: | In critically ill patients, either arterial or venous blood is usually available for sampling and measurement of basic coagulation parameters. The aim of this study was to examine whether in these patients the values of coagulation parameters differ significantly with respect to the source of the blood samples. In a group of 44 patients with severe sepsis, we compared the values of coagulation, thromboelastography and selected hematological parameters between the arterial and venous blood. In most of the investigated parameters (international normalized ratio, activated partial thromboplastin time, fibrinogen concentration, erythrocyte count, leukocyte and platelet count, hemoglobin level and thromboelastography parameters), we did not find significant differences (P > 0.1). However, we found a significantly lower antithrombin activity and a significantly higher D-dimer concentration in venous blood compared to arterial blood (P < 0.05). This could be associated with increased consumption of antithrombin and generation of D-dimer as a consequence of microthrombi formation in the capillaries. We therefore conclude that for the purpose of assessment of coagulation status in septic patients, arterial and venous blood cannot be treated as equivalent. |
Databáze: | OpenAIRE |
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