Use of a Long-acting Inhaled β2-Adrenergic Agonist, Salmeterol Xinafoate, in Patients with Chronic Obstructive Pulmonary Disease
| Autor: | Joseph O. Broughton, Wayne Anderson, Kathleen A. Rickard, Mitchell Friedman, Richard ZuWALLACK, Michael Wisniewski, William Bailey, Stephen I. Rennard |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Agonist medicine.drug_class Vital Capacity Ipratropium bromide Critical Care and Intensive Care Medicine Placebo Cholinergic Antagonists Double-Blind Method immune system diseases Forced Expiratory Volume Bronchodilator medicine Humans Albuterol Lung Diseases Obstructive Salmeterol Xinafoate Analysis of Variance COPD business.industry Ipratropium Adrenergic beta-Agonists Middle Aged respiratory system medicine.disease Bronchodilator Agents respiratory tract diseases Bronchodilatation Anesthesia Quality of Life Female Salmeterol business medicine.drug |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine. 163:1087-1092 |
| ISSN: | 1535-4970 1073-449X |
| Popis: | Chronic obstructive pulmonary disease (COPD) is a condition in which continuous bronchodilation may have clinical advantages. This study evaluated salmeterol, a beta-agonist bronchodilator with a duration of action substantially longer than that of short-acting beta-agonists, compared with ipratropium, an anticholinergic bronchodilator, and placebo in patients with COPD. Four hundred and five patients with COPD received either salmeterol 42 microg twice daily, ipratropium bromide 36 microg four times daily, or placebo for 12 wk in this randomized, double-blind, parallel-group study. Patients were stratified on the basis of bronchodilator response to albuterol (12% and200-ml improvement) and were randomized within each stratum. Bronchodilator response was measured over 12 h four times during the treatment period. Salmeterol provided similar maximal bronchodilatation to ipratropium but had a longer duration of action and a more constant bronchodilatory effect with no evidence of bronchodilator tolerance. Both active treatments were well tolerated. Salmeterol was an effective bronchodilator with a consistent effect over this 12-wk study in patients with COPD, including those "unresponsive" to albuterol. The long duration of action of salmeterol offers the advantage of twice daily dosing compared with the required four times a day dosing with ipratropium. |
| Databáze: | OpenAIRE |
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