Accuracy of PTH assay and corrected calcium in early prediction of hypoparathyroidism after thyroid surgery
| Autor: | Ottavio Cavicchi, Ottavio Piccin, Domenico Saggese, U. Caliceti, Carla Bordonaro, Ignacio Javier Fernandez, Alberto Rinaldi Ceroni |
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| Přispěvatelé: | O.Cavicchi, O.Piccin, U.Caliceti, I. J. Fernandez, C.Bordonaro, D.Saggese, A.Rinaldi Ceroni |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Adolescent Hypoparathyroidism medicine.medical_treatment Parathyroid hormone chemistry.chemical_element Calcium Postoperative Complications Predictive Value of Tests Medicine Humans Prospective Studies Prospective cohort study Aged Aged 80 and over Corrected calcium business.industry Thyroid Albumin Thyroidectomy Reproducibility of Results Middle Aged medicine.disease Prognosis Surgery medicine.anatomical_structure Otorhinolaryngology chemistry Parathyroid Hormone Female business Algorithms |
| Zdroj: | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 138(5) |
| ISSN: | 0194-5998 |
| Popis: | To evaluate the accuracy of the intraoperative parathyroid hormone (ioPTH) and 6-hour PTH (6hPTH) assay in predicting transient hypoparathyroidism after thyroidectomy.A nonrandomized prospective study was conducted on patients undergoing thyroid surgery.Of 138 patients undergoing thyroid surgery, intraoperative PTH was measured 10 minutes after gland removal. Serum calcium, magnesium, inorganic phosphorus, albumin, and PTH levels were assayed 6 and 16 hours after surgery and daily until patient discharge.The development of postoperative hypocalcemia was associated with low ioPTH (P0.0001) and 6hPTH (P0.0001) values, and the decline of PTH from baseline (P0.0001). The cutoff for percentage decline of ioPTH and 6hPTH (55.7% and 379%, respectively) was more accurate than an absolute value. Accuracy, and positive and negative predictive values were 88 percent, 63 percent, and 100 percent for ioPTH and 75 percent, 46 percent, and 100 percent for 6hPTH, respectively.With the use of ioPTH decline in association with 16-hour corrected calcium, it is possible to distinguish early normocalcemic patients from hypocalcemic ones in most cases. |
| Databáze: | OpenAIRE |
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