OVCA (CA125) second generation: technical aspects and serum levels in controls, patients with liver disease, pregnant women and patients with ovarian disease
| Autor: | Mario Fratta, Patrizia Gazzerro, A. Tucci, B. Di Finizio, Anna Maria Molinari, Michele Cioffi |
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| Přispěvatelé: | Cioffi, Michele, Fratta, M, Gazzerro, P, DI FINIZIO, B, Tucci, A, Molinari, Anna Maria |
| Rok vydání: | 1997 |
| Předmět: |
Cancer Research
medicine.medical_specialty endocrine system diseases Gastroenterology 030218 nuclear medicine & medical imaging Ovarian disease 03 medical and health sciences Liver disease 0302 clinical medicine Pregnancy Reference Values Internal medicine Medicine Humans Ovarian Diseases Ovarian Neoplasms business.industry Liver Diseases Significant difference Cancer General Medicine medicine.disease female genital diseases and pregnancy complications Endocrinology Oncology 030220 oncology & carcinogenesis CA-125 Antigen Female Immunoradiometric Assay business Ovarian cancer |
| Zdroj: | Europe PubMed Central |
| ISSN: | 0300-8916 |
| Popis: | An immunoradiometric method of the second generation (IRMA II) is widely used to determine CA125 serum levels. In this study we have evaluated the performance characteristics of a commercially available IRMA CA125 II (Byk-Gulden, Sangtec Diagnostics). The CA125 serum levels were determined in several groups of patients (healthy women, pregnant women, subjects affected by benign and malignant ovarian cancer, patients with liver diseases) with two IRMAs CA125 II (Byk-Gulden, Sangtec Diagnostica and Centocor, Diagnostic Division) and IRMA CA125 I (Byk-Gulden, Sangtec Diagnostica). Our results show a good analytic performance of IRMA CA125 II (Byk-Gulden, Sangtec Diagnostica), a good correlation between IRMAs CA125 II (Byk-Gulden, Sangtec Diagnostica and Centocor, Diagnostic Division), but an unacceptable correlation between IRMAs CA125 II (Byk-Gulden, Sangtec Diagnostica and Centocor, Diagnostic Division) and IRMA CA125 I. A statistically significant difference was observed comparing the values obtained with both IRMAs CA125 II and IRMA CA125 I in the groups of patients. In contrast no statistically significant difference was observed when we compared the values obtained with IRMA CA125 II (Byk-Gulden, Sangtec Diagnostica) and IRMA CA125 II (Centocor, Diagnostic Division). CA125 serum values obtained with the second-generation kits were different from those obtained with the first-generation one; consequently, it is important, especially in the follow-up of cancer patients, that CA125 serum values be obtained with kits of the same generation. Our data seem to suggest the use of second-generation kits to determine CA125 serum levels. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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