Excessive fuel availability amplifies the FTO-mediated obesity risk: results from the TUEF and Whitehall II studies
| Autor: | Sebastian M. Schmid, Martin Heni, Benjamin Assad Jaghutriz, Fausto Machicao, Róbert János Bánhegyi, Adam G. Tabak, Ellen Fehlert, Andreas Peter, Hans-Ulrich Häring, Robert Wagner, Harald Staiger, Andreas Fritsche, Louise Fritsche |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Blood Glucose Male lcsh:Medicine Type 2 diabetes Weight Gain Body Mass Index chemistry.chemical_compound 0302 clinical medicine Longitudinal Studies Prospective Studies lcsh:Science Multidisciplinary Fasting Middle Aged Female medicine.symptom Glycolysis Adult medicine.medical_specialty Genotype Energy metabolism Alpha-Ketoglutarate-Dependent Dioxygenase FTO 030209 endocrinology & metabolism Polymorphism Single Nucleotide Article 03 medical and health sciences Internal medicine Diabetes mellitus medicine Humans Genetic Predisposition to Disease Obesity Triglycerides Triglyceride business.industry lcsh:R Weight change Body Weight nutritional and metabolic diseases medicine.disease Lipid Metabolism 030104 developmental biology Endocrinology chemistry lcsh:Q business Energy Metabolism Body mass index Weight gain |
| Zdroj: | Scientific Reports Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017) Sci. Rep. 7:15486 (2017) |
| ISSN: | 2045-2322 |
| Popis: | Variation in FTO is the most important common genetic determinant of body weight. Altered energy metabolism could underlie this association. We hypothesized that higher circulating glucose or triglycerides can amplify the FTO impact on BMI. In 2671 subjects of the TUEF study, we investigated the interaction effect of fasting glucose and triglyceride levels with rs9939609 in FTO on BMI. We analysed the same interaction effect by longitudinally utilizing mixed effect models in the prospective Whitehall II study. In TUEF, we detected an interaction effect between fasting glucose and fasting triglycerides with rs9939609 on BMI (p = 0.0005 and p = 5 × 10(-7), respectively). The effect size of one risk allele was 1.4 ± 0.3 vs. 2.2 ± 0.44 kg/m² in persons with fasting glucose levels below and above the median, respectively. Fasting triglycerides above the median increased the per-allele effect from 1.4 ± 0.3 to 1.7 ± 0.4 kg/m(2). In the Whitehall II study, body weight increased by 2.96 ± 6.5 kg during a follow-up of 13.5 ± 4.6 yrs. Baseline fasting glucose and rs9939609 interacted on weight change (p = 0.009). Higher fasting glucose levels may amplify obesity-risk in FTO carriers and lead to an exaggerated weight gain over time. Since weight gain perpetuates metabolic alterations, this interplay may trigger a vicious circle that leads to obesity and diabetes. |
| Databáze: | OpenAIRE |
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