Radio-guided brain tumorectomy using a gamma detecting probe and a mobile solid-state gamma camera
| Autor: | Tatsuo Kumazaki, Akira Teramoto, Fumio Yamaguchi, Takayuki Kitamura, Sunao Mizumura, Toyoyuki Kojima, Shinichiro Kumita |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Technetium Tc 99m Sestamibi Neoplasm Residual medicine.medical_treatment Solid-state chemistry.chemical_element Single-photon emission computed tomography Astrocytoma Scintigraphy Technetium law.invention Imaging Three-Dimensional law medicine Image Processing Computer-Assisted Humans Gamma Cameras Craniotomy Gamma camera Aged Tomography Emission-Computed Single-Photon medicine.diagnostic_test business.industry Brain Neoplasms Brain Middle Aged Treatment Outcome chemistry Surgery Computer-Assisted Surgery Female Neurology (clinical) Neoplasm Recurrence Local business Nuclear medicine Glioblastoma Gamma probe Follow-Up Studies |
| Zdroj: | Surgical neurology. 61(3) |
| ISSN: | 0090-3019 |
| Popis: | Background We herein report a technique to distinguish brain tumors from normal brain tissue during surgery using a gamma probe and a solid-state mobile gamma camera after 99mTc-hexakis-2-methoxy-isobutyl-isonitrile (99mTc-MIBI) is administered to patients immediately before operation. Methods We examined 13 patients with brain tumors. Before the operation, 99mTc-MIBI single photon emission computed tomography (SPECT) was performed to assess accumulation in the tumors. On the day of the operation, 99mTc-MIBI was administered intravenously and craniotomy for tumor resection was performed. During the operation, the tumor was localized with a gamma probe and preremoval scintigraphy images were taken with a mobile gamma camera. After tumor resection was completed, residual tumors were confirmed using it again. We compared accumulation found in the preoperative SPECT images and intraoperative scintigraphy images, performed a histologic examination of adjacent tissues, and measured the dose the personnel was exposed to per operation. Results In all patients, tumors were confirmed by a gamma probe and scintigraphy during the operation. Intraoperative accumulation in tumors was significantly related to accumulation found in the preoperative 99mTc-MIBI SPECT images. In 9 out of 13 patients, accumulation disappeared in the postremoval scintigraphy images, and no tumor tissue was found by histologic examination. Residual tumor tissue was found in 4 patients. Average exposure of the personnel per operation was 22.9 ± 4.0 μSv. Conclusion Resection of brain tumors with a gamma probe and a mobile gamma camera was very useful since the area to be removed was easily identified and residual tumors could be detected. |
| Databáze: | OpenAIRE |
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