Long-term follow-up of biomarkers of vascular calcification after switch from traditional hemodialysis to online hemodiafiltration

Autor: Marjo H. J. Knapen, Anders Fernström, Cees Vermeer, Per Magnusson, Fredrik Uhlin
Přispěvatelé: RS: CARIM - R1.02 - Vascular aspects thrombosis and haemostasis, RS: Carim - B02 Vascular aspects thrombosis and Haemostasis
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Time Factors
osteopontin
medicine.medical_treatment
Clinical Biochemistry
030232 urology & nephrology
030204 cardiovascular system & hematology
BONE ALKALINE-PHOSPHATASE
0302 clinical medicine
Matrix gla protein
pulse wave analysis
Osteopontin
FETUIN-A
VITAMIN-K
ALL-CAUSE MORTALITY
biology
AORTIC STIFFNESS
MATRIX GLA PROTEIN
General Medicine
POSTMENOPAUSAL WOMEN
vascular calcification
CARDIOVASCULAR-DISEASE
renal dialysis
Cardiology
Female
lipids (amino acids
peptides
and proteins)
Hemodialysis
medicine.symptom
ARTERIAL STIFFNESS
medicine.medical_specialty
Long term follow up
Inflammation
Online Systems
Statistics
Nonparametric
03 medical and health sciences
Vascular Stiffness
Osteoprotegerin
Internal medicine
Alkaline phosphatase
medicine
Humans
Vascular calcification
Aged
hemodiafiltration
chronic renal insufficiency
OSTEOPROTEGERIN
business.industry
medicine.disease
Arterial stiffness
biology.protein
business
Biomarkers
chronic kidney disease
Follow-Up Studies
Zdroj: Scandinavian Journal of Clinical & Laboratory Investigation, 79(3), 174-181. Routledge/Taylor & Francis Group
ISSN: 0036-5513
DOI: 10.1080/00365513.2019.1576218
Popis: Rapid progression of vascular calcification (VC) in hemodialysis (HD) patients is caused by several factors including inflammation and an imbalance between active inducers and inhibitors of VC. Growing evidence shows that online hemodiafiltration (ol-HDF), a combination of diffusive and convective solute transport, has positive effects on the uremic environment that affects patients on dialysis. However, we recently reported that serum 25-hydroxyvitamin D (25(OH)D) decreased after a switch from HD to ol-HDF. As a consequence of this finding, the present study was undertaken to investigate if inducers and inhibitors of VC (i.e. the inactive matrix Gla protein fractions dp-ucMGP and t-ucMGP, fetuin-A, Gla-rich protein (GRP), osteopontin (OPN), bone-specific alkaline phosphatase (BALP), and osteoprotegerin (OPG)) also are affected by ol-HDF. This non-comparative prospective study comprised 35 prevalent patients who were investigated 6, 12, and 24 months after their switch from HD to ol-HDF. Most patients had increased levels of the calcification inhibitors OPN and OPG; and of the inactive calcification inhibitor dp-ucMGP during the study period irrespective of the dialysis modality. BALP and t-ucMGP were mostly within the reference interval, but fetuin-A was mostly below the reference interval during the study period. OPN was significantly associated with BALP and parathyroid hormone, r = 0.62 and r = 0.65 (p
Databáze: OpenAIRE
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