Reinnervation of Pancreatic Islets and Regulation of Insulin Secretion by Hepatic Sympathetic Nerves after Intraportal Transplantation of Islets into Livers of Diabetic Rats
| Autor: | L. Cossel, Grosse, W. Hildebrandt, Andreas Gardemann, H J Hahn, F. Wohlrab, Blech W, Jungermann K |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
endocrine system
medicine.medical_specialty Sympathetic Nervous System endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Islets of Langerhans Transplantation 030209 endocrinology & metabolism 030230 surgery Diabetes Mellitus Experimental Islets of Langerhans 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Internal Medicine medicine Animals Insulin Catecholaminergic geography geography.geographical_feature_category Portal Vein business.industry Pancreatic islets General Medicine Glucagon Islet Electric Stimulation Rats 3. Good health Insulin oscillation Transplantation medicine.anatomical_structure Liver Cholinergic business Liver Circulation Reinnervation |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 103:107-111 |
| ISSN: | 1439-3646 0947-7349 |
| DOI: | 10.1055/s-0029-1211405 |
| Popis: | It was the aim of this study to elucidate whether intraportally transplanted pancreatic islets were reinnervated after transplantation and whether the secretion of insulin from pancreatic islets might be modulated by the vegetative innervation of recipient livers. Two weeks after intraportal transplantation of 2000 neonatal pancreatic islets recipient rats completely recovered from streptozotocin-induced diabetes. Predominantly catecholaminergic, but also cholinergic nerve fibers were detected in islet cell complexes between beta-cells. Corresponding electron micrographs showed beta-cells in close contact with axons of nonmyelinated nerve fibers. Perfusion studies with livers of recipient rats revealed that the inhibition by hepatic sympathetic nerves of insulin secretion was mediated via alpha 2-receptors as in normal pancreatic islets. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|