Regenerative capacity of human satellite cells: the mitotic clock in cell transplantation
| Autor: | G. Piron-Hamelin, Cyrille Forestier, Valérie Renault, R. Amouri, S. Di Donna, Fayçal Hentati, Gillian Butler-Browne, Racquel N. Cooper, Vincent Mouly, D. Thiesson, Elodie Ponsot, S. Decary |
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| Rok vydání: | 2000 |
| Předmět: |
Telomerase
Genetic enhancement Genetic Vectors Muscle Fibers Skeletal Mitosis Dermatology Biology Muscular Dystrophies Biological Clocks Putative gene medicine Animals Humans Cellular Senescence Skeletal muscle Genetic Therapy General Medicine Telomere biology.organism_classification Cell biology Transplantation Psychiatry and Mental health medicine.anatomical_structure Tissue Transplantation Immunology Satellite (biology) Neurology (clinical) Cellular model |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1590-3478 1590-1874 |
| DOI: | 10.1007/s100720070008 |
| Popis: | In this communication, we will review the problems caused by cell-mediated gene therapy, taking skeletal muscle as a physiological model. In particular we have utilised vectors transferring telomerase under the control of retroviral promoters into human satellite cells. The set of results presented here has several implications regarding gene therapy trials. Nevertheless, more experiments will be required to fully validate this cellular model and to use telomerase to safely extend the lifespan of putative gene therapy vectors. |
| Databáze: | OpenAIRE |
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