Renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion: Radiological findings mimicking papillary subtype
| Autor: | Yoshinobu Hirose, Kengo Horie, Kousei Miwa, Hiroki Kato, Takashi Deguchi, Shigeaki Yokoi, Masayuki Kanematsu |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Pathology medicine.medical_specialty Adolescent Chromosomal translocation TFE3 Translocation Genetic Diagnosis Differential Fusion gene Lesion Renal cell carcinoma Carcinoma Humans Medicine Radiology Nuclear Medicine and imaging Carcinoma Renal Cell Pathological medicine.diagnostic_test Basic Helix-Loop-Helix Leucine Zipper Transcription Factors business.industry Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Carcinoma Papillary Kidney Neoplasms Radiology Gene Fusion medicine.symptom Tomography X-Ray Computed business |
| Zdroj: | Journal of Magnetic Resonance Imaging. 33:217-220 |
| ISSN: | 1053-1807 |
| Popis: | The authors describe the computed tomography (CT) and magnetic resonance imaging (MRI) findings of an 18-year-old man with renal cell carcinoma (RCC) associated with the Xp11.2 translocation/transcription factor E3 (TFE3) gene fusion (Xp11 translocation carcinoma). The lesion was hyperdense on unenhanced CT, hypovascular on contrast-enhanced studies, hypointense on T2-weighted MR images, and hemosiderin deposition was suspected on phase-shift gradient-echo MR images. Histopathological specimens revealed pathological findings resembling papillary RCC predominantly and exhibited immunoreactivity for TFE3. Because there is often considerable morphological overlap between this carcinoma and papillary RCC, the imaging findings of Xp11 translocation carcinoma may be similar to those of the papillary subtype. Therefore, Xp11 translocation carcinoma should be considered, particularly in young patients when radiologic images demonstrate a renal tumor mimicking the papillary subtype. |
| Databáze: | OpenAIRE |
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