Acid-base disturbances in acute poisoning and their association with survival
| Autor: | Hossein Hassanian-Moghaddam, Haleh Hamdi, Amir Hamdi, Narges Sadat Zahed |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Critical Care Iran Critical Care and Intensive Care Medicine Respiratory compensation 03 medical and health sciences 0302 clinical medicine Internal medicine Severity of illness medicine Humans 030212 general & internal medicine Intensive care medicine Survival analysis Aged Retrospective Studies Acidosis Psychotropic Drugs business.industry Poisoning 030208 emergency & critical care medicine Metabolic acidosis Retrospective cohort study Odds ratio Hydrogen-Ion Concentration Middle Aged medicine.disease Survival Analysis Hospitalization Intensive Care Units Cross-Sectional Studies Point-of-Care Testing Respiratory alkalosis Female Blood Gas Analysis medicine.symptom business |
| Zdroj: | Journal of Critical Care. 35:84-89 |
| ISSN: | 0883-9441 |
| DOI: | 10.1016/j.jcrc.2016.05.003 |
| Popis: | The purpose was to investigate the association between acid-base disturbances and mortality in acute poisoning.We performed a retrospective cross-sectional exploratory study on all acutely poisoned patients older than 12 years who had been admitted to the main tertiary toxicology hospital in Tehran between March and August 2010.Of a total of 1167 patients (median age=25 years, 50.9% male), 98 died (74.5% male). Psychotropic medications were the most common cause of poisoning (36.5%), whereas narcotics and psychodysleptics were the most common cause of death (23.5%). Mixed respiratory alkalosis and metabolic acidosis with normal pH were the most common acid-base status (333, 28.5%). However, patients with primary metabolic acidosis and respiratory compensation had significantly higher mortality (31 cases, 18.8%). Logistic regression analysis identified age (odds ratio [OR], 1.051; 95% confidence interval [CI], 1.031-1.070; P.001), intensive care unit admission (OR, 12.405; 95% CI, 7.178-21.440; P.001), consciousness level (OR, 1.752; 95% CI, 1.301-2.359; P.001), hospitalization period (OR, 1.1361; 95% CI, 1.079-1.195; P.001), severe metabolic acidosis (OR, 6.016; 95% CI, 1.647-21.968; P=.007), and primary respiratory alkalosis (OR, 5.579; 95% CI, 1.353-23.001; P=.017) as death predictors during hospitalization (P.001).On-arrival acid-base status predicts survival and can be used in prognostication of the poisoned patients. |
| Databáze: | OpenAIRE |
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