The impact of IgG antibodies to recombinant Plasmodium falciparum 732var CIDR-1α domain in mothers and their newborn babies
| Autor: | Yu-Shan Chia, Philippe Deloron, Jürgen May, Jean-Yves Le Hesran, Ayman Khattab, Mo-Quen Klinkert |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
CD36 Antigens Placenta Plasmodium falciparum Protozoan Proteins Antigens Protozoan Receptors Cell Surface medicine.disease_cause law.invention Apicomplexa Pregnancy law medicine Animals Humans Malaria Falciparum Escherichia coli General Veterinary biology Chinese hamster ovary cell Chondroitin Sulfates Infant Newborn General Medicine medicine.disease biology.organism_classification Virology Recombinant Proteins Infectious Diseases medicine.anatomical_structure Immunoglobulin G Pregnancy Complications Parasitic Insect Science biology.protein Recombinant DNA Female Parasitology Antibody Duffy Blood-Group System Malaria |
| Zdroj: | Parasitology Research. 101:767-774 |
| ISSN: | 1432-1955 0932-0113 |
| Popis: | Different domains of a novel full-length var gene (termed 732var) isolated from a placenta of a malaria-infected woman were expressed in Escherichia coli as recombinant proteins and analysed biochemically and immunologically. Two of these, the Duffy binding-like (DBL)-3gamma domain and the cysteine-rich interdomain region (CIDR)-1alpha were able to bind chondroitin sulfate A and CD36, respectively. The DBL-3gamma domain was investigated in a previous study and confirmed here to exhibit anti-disease characteristics related to pregnancy-associated malaria. Mothers with high anti-DBL-3gamma antibody levels were protected from placental infection. The novel finding in this study is that babies born to mothers carrying anti-CIDR-1alpha antibodies had a delayed time to the first infection. |
| Databáze: | OpenAIRE |
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