Association of ADIPOQ variants, total and high molecular weight adiponectin levels with coronary artery disease in diabetic and non-diabetic Brazilian subjects
| Autor: | Gilberto Velho, Pedro Saddi-Rosa, André F. Reis, José Gilberto H. Vieira, Fernando M. A. Giuffrida, Luis Henrique Santos Canani, Fernando Gerchman, Carolina S. V. Oliveira, Felipe Crispim |
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| Rok vydání: | 2011 |
| Předmět: |
Coronary angiography
Blood Glucose Male medicine.medical_specialty Diabetic Cardiomyopathies Endocrinology Diabetes and Metabolism Coronary Artery Disease Coronary Angiography Polymorphism Single Nucleotide Coronary artery disease Endocrinology High molecular weight adiponectin Internal medicine Diabetes mellitus Internal Medicine medicine Prevalence Humans Insulin Genetic Predisposition to Disease Hmw adiponectin Genetic Association Studies Glycemic Aged Glycated Hemoglobin Adiponectin business.industry nutritional and metabolic diseases food and beverages Genetic Variation Middle Aged medicine.disease Lipids Diabetes Mellitus Type 2 Female business hormones hormone substitutes and hormone antagonists Brazil Non diabetic |
| Zdroj: | Journal of diabetes and its complications. 26(2) |
| ISSN: | 1873-460X |
| Popis: | Objective To investigate the association of ADIPOQ variants, total and high molecular weight adiponectin (HMW) adiponectin levels with the prevalence of diabetes mellitus and coronary artery disease (CAD) diagnosed by coronary angiography in Brazilian subjects with high cardiovascular risk. Methods 603 subjects undergoing coronary angiography were studied in regard to their glycemic status and presence of CAD (lesions > 0%). We evaluated baseline concentrations of total and HMW adiponectin and three ADIPOQ variants: − 11391G > A (rs17300539), + 45T > G (rs2241766) and + 276G > T (rs1501299). Results The G-allele of rs2241766 was associated with higher levels of total and HMW adiponectin, and the A-allele of rs17300539 was associated with higher levels of HMW adiponectin. Lower levels of total and HMW adiponectin were independently associated with CAD. The G-allele of rs2241766 (OR 2.45, 95% C.I. 1.05–6.04, p = 0.04) and the G-allele of rs1501299 (OR 1.89, 95% C.I. 1.04–3.45, p = 0.03) were associated with CAD, and these associations were independent of circulating levels of adiponectin. Conclusions In Brazilian subjects with high cardiovascular risk, CAD was associated with lower total and HMW adiponectin levels. The rs2241766 and rs1501299 polymorphisms were associated with CAD. The rs2241766 variant was associated with total and HMW adiponectin levels, while rs17300539 was associated with HMW adiponectin levels. |
| Databáze: | OpenAIRE |
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