Follistatin and Activin: A Potential Intrinsic Regulatory System within Diverse Tissues
| Autor: | Louis V. DePaolo, Gregory F. Erickson, Thomas A. Bicsak, Shunichi Shimasaki, Nicholas Ling |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Follistatin
endocrine system medicine.medical_specialty endocrine system diseases Regulator General Biochemistry Genetics and Molecular Biology law.invention Muscle hypertrophy Mice Anterior pituitary law Internal medicine medicine Animals Humans Inhibins Tissue Distribution Secretion Glycoproteins biology Ovary Cell Differentiation Follicular fluid Activins Rats medicine.anatomical_structure Endocrinology Gene Expression Regulation Pituitary Gland biology.protein Suppressor Cattle Female Follicle Stimulating Hormone Cell Division hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Experimental Biology and Medicine. 198:500-512 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-198-43286a |
| Popis: | Until the 1920s, it was assumed that the sole gonadal hormones modulating anterior pituitary glandular secretions were lipid-soluble entities called steroids. Experimental evidence then surfaced during the ensuing decade that demonstrated that the testis also contained a hydrophilic material that might also influence pituitary secretory activity (1, 2). The name “inhibin” was given to this novel substance in view of its ability to inhibit hypertrophy of pituitary cells in castrated rats (2). Work in later years evoked the concept that inhibin could be an important regulator of follicle-stimulating hormone (FSH) secretion (3, 4). Thus, as a consequence of these landmark studies, investigators began a search to elucidate the chemical nature of the inhibins.Although inhibin was discovered as a potential secretory product of the testis, it was almost 45 years later that a nonsteroidal FSH suppressor was demonstrated in the ovarian follicular fluid of cows (5). Ironically, it was the ovarian follicular fluid f... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|