Biochemical effects on kidney of exposure to high concentrations of dimethyl sulphoxide
| Autor: | S.J. Baxter, G.H. Lathe |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
Male
Cytoplasm ATPase Lysine In Vitro Techniques Mitochondrion Cell Fractionation Kidney Biochemistry Oxidative Phosphorylation Phosphoenolpyruvate chemistry.chemical_compound Oxygen Consumption Respiration Animals Urea Dimethyl Sulfoxide Glycolysis Pyruvates Adenosine Triphosphatases Cell Nucleus Pharmacology Chromatography biology Fructosephosphates Glucosephosphates Metabolism Fructose-Bisphosphatase Mitochondria Rats Enzyme Activation Glucose chemistry Anaerobic glycolysis Glycerophosphates Chromatography Gel Lactates biology.protein |
| Zdroj: | Biochemical Pharmacology. 20:1079-1091 |
| ISSN: | 0006-2952 |
| DOI: | 10.1016/0006-2952(71)90337-6 |
| Popis: | Kidney preparations were exposed to up to 30% dimethyl sulphoxide at various temperatures following which the dimethyl sulphoxide was removed or diluted out, and metabolism was examined at 37°. Respiration of slices and mitochondria and the P/O ratios and respiratory control index of mitochondria were little affected by 30% dimethyl sulphoxide at 4°. Homogenate respiration and nuclear ATPase were inhibited. Anaerobic glycolysis of slices and homogenates were much reduced, due in part to activation of FDPase by dimethyl sulphoxide. Activation of FDPase, and inhibition of glycolysis could be prevented by adding urea or lysine with the dimethyl sulphoxide. |
| Databáze: | OpenAIRE |
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