dbCNS: A New Database for Conserved Noncoding Sequences
Autor: | Jun G. Inoue, Naruya Saitou |
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Rok vydání: | 2020 |
Předmět: |
dbSNP
Biology AcademicSubjects/SCI01180 computer.software_genre Genome Protein expression biology.animal conserved noncoding sequences single-nucleotide polymorphisms Genetics Animals Humans Test analysis Molecular Biology Gene Conserved Sequence Ecology Evolution Behavior and Systematics Base Sequence Database Phylogenetic tree AcademicSubjects/SCI01130 Vertebrate Resources cis-regulatory elements Vertebrates Identification (biology) Databases Nucleic Acid dbCNS computer |
Zdroj: | Molecular Biology and Evolution |
ISSN: | 1537-1719 |
Popis: | We developed dbCNS (http://yamasati.nig.ac.jp/dbcns), a new database for conserved noncoding sequences (CNSs). CNSs exist in many eukaryotes and are assumed to be involved in protein expression control. Version 1 of dbCNS, introduced here, includes a powerful and precise CNS identification pipeline for multiple vertebrate genomes. Mutations in CNSs may induce morphological changes and cause genetic diseases. For this reason, many vertebrate CNSs have been identified, with special reference to primate genomes. We integrated ∼6.9 million CNSs from many vertebrate genomes into dbCNS, which allows users to extract CNSs near genes of interest using keyword searches. In addition to CNSs, dbCNS contains published genome sequences of 161 species. With purposeful taxonomic sampling of genomes, users can employ CNSs as queries to reconstruct CNS alignments and phylogenetic trees, to evaluate CNS modifications, acquisitions, and losses, and to roughly identify species with CNSs having accelerated substitution rates. dbCNS also produces links to dbSNP for searching pathogenic single-nucleotide polymorphisms in human CNSs. Thus, dbCNS connects morphological changes with genetic diseases. A test analysis using 38 gnathostome genomes was accomplished within 30 s. dbCNS results can evaluate CNSs identified by other stand-alone programs using genome-scale data. |
Databáze: | OpenAIRE |
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