Improved Occlusion Rate of Intracranial Aneurysms Treated with the Derivo Embolization Device: One-Year Clinical and Angiographic Follow-Up in a Multicenter Study
| Autor: | Jan Borggrefe, Christoph Kabbasch, Marc Schlamann, Robert Forbrig, Franziska Dorn, Bastian Kraus, Thomas Liebig, Bernd Turowski, Lukas Goertz |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Brain Ischemia 03 medical and health sciences Young Adult 0302 clinical medicine Aneurysm Postoperative Complications Occlusion Medicine Humans Embolization Adverse effect Aged Retrospective Studies medicine.diagnostic_test business.industry Stent Retrospective cohort study Intracranial Aneurysm Middle Aged medicine.disease Thrombosis Embolization Therapeutic Surgery Cerebral Angiography Stroke Treatment Outcome 030220 oncology & carcinogenesis Angiography Female Neurology (clinical) business 030217 neurology & neurosurgery Platelet Aggregation Inhibitors Follow-Up Studies |
| Zdroj: | World neurosurgery. 126 |
| ISSN: | 1878-8769 |
| Popis: | Objective The Derivo Embolization Device (DED) is a novel flow-diverter stent consisting of a flexible structure and a surface modification that aims to reduce thrombogenicity. Here, we report 1-year clinical and angiographic follow-up results of the second-generation DED for the treatment of intracranial aneurysms. Methods This is a retrospective study of 59 consecutive patients (mean age: 53 years, 81% women) treated with the DED for 59 aneurysms (mean size: 8.1 mm) between November 2015 and February 2018 at 3 German tertiary care centers. We evaluated the rate of ischemic stroke, functional outcome, and angiographic results during a 1-year follow-up period. Results Deployment of the DED was successful in all cases. Adverse events were observed in 6 procedures (10.2%), of which 2 were symptomatic (3.4%). No delayed ischemic or hemorrhagic events occurred during the 1-year follow-up and there were no deaths. Permanent morbidity due to in-stent thrombosis and consecutive ischemic stroke occurred in 1 patient (1.7%). Complete (O'Kelly-Marotta grading scale D) and favorable (O'Kelly-Marotta grading scale C+D) aneurysm occlusion was obtained in 70.5% (31/44) and 88.7% (39/44) at 6 months and 82.8% (24/29) and 100% (29/29) at 12 months, respectively. Conclusions Our results demonstrate that treatment of intracranial aneurysms with the DED is associated with low rates of ischemic complications and adequate aneurysm occlusion at 1-year follow-up. |
| Databáze: | OpenAIRE |
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