Multiple plasma metals, genetic risk and serum C-reactive protein: A metal-metal and gene-metal interaction study
| Autor: | Pinpin Long, Frank B. Hu, Yang Xiao, Tingting Mo, Xiaomin Zhang, Handong Yang, Xuezhen Liu, Tangchun Wu, Meian He, Lue Zhou, Kang Liu, Shiqi He, Ana Navas-Acien, An Pan, Ce Zhang, Xinwen Min, Jun Li, Xiulou Li, Hao Wang, Yanqiu Yu, Yu Yuan, Yiyi Liu |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Gene-metal interaction Clinical Biochemistry chemistry.chemical_element Inflammation Biochemistry C-reactive protein Metal 03 medical and health sciences Selenium 0302 clinical medicine Risk Factors Internal medicine Genetic predisposition medicine Humans Genetic risk Metal-metal interaction lcsh:QH301-705.5 Gene lcsh:R5-920 biology Chemistry Organic Chemistry Genetic risk score 3. Good health Zinc 030104 developmental biology Endocrinology lcsh:Biology (General) Metals visual_art visual_art.visual_art_medium biology.protein Biomarker (medicine) medicine.symptom lcsh:Medicine (General) 030217 neurology & neurosurgery Copper Research Paper |
| Zdroj: | Redox Biology Redox Biology, Vol 29, Iss, Pp-(2020) |
| ISSN: | 2213-2317 |
| Popis: | Background C-reactive protein (CRP) is a well-recognized biomarker of inflammation, which can be used as a predictor of cardiovascular disease. Evidence have suggested exposure to multiple metals/metalloids may affect immune system and give rise to cardiovascular disease. However, it is lack of study to comprehensively evaluate the association of multiple metals and CRP, the interactions between metals, and the gene-metal interaction in relation to CRP levels. Aims To explore the associations of multiple plasma metals with serum CRP, and to test the interactions between metals, and gene-metal interactions on the levels of serum CRP. Methods We included 2882 participants from the Dongfeng-Tongji cohort, China, and measured 23 plasma metals and serum CRP concentrations. The genetic risk score (GRS) was calculated based on 7 established CRP-associated variants. For metals which were associated with the levels of CRP, we further tested the interactions between metals on CRP, and analyzed the gene-metal interactions on CRP. Results The median level for CRP in the total population was 1.17 mg/L. After multivariable adjustment, plasma copper was positively associated with serum CRP (FDR Highlights • We found that serum CRP was positively associated with plasma copper, and inversely associated with selenium. • The positive association of plasma copper with serum CRP appeared to be attenuated with high plasma zinc and selenium. • This is the first study that explored the potential gene-metal interactions in relation to CRP levels. • These novel findings may provide new insights to personalized prevention and interventions for inflammation. |
| Databáze: | OpenAIRE |
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