Expression of CD45 isoforms in chronic B-cell leukaemias
| Autor: | Rosemary L. Sparrow, Derek N.J. Hart, Martin B. Van Der Weyden, Heddy Zola, Naomi Siderius, Andrew W. Boyd, Sue Houghton, J. C. Nimmo, L. Flego |
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| Rok vydání: | 1993 |
| Předmět: |
Gene isoform
Cancer Research Chronic lymphocytic leukemia Disease Biology CD5 Antigens Epitope Isomerism Antigens CD Antigens Neoplasm immune system diseases hemic and lymphatic diseases medicine Humans B cell B-Lymphocytes Lymphocytic leukaemia Hairy cell leukaemia Hematology medicine.disease Leukemia Lymphocytic Chronic B-Cell Phenotype Molecular biology Lymphoproliferative Disorders medicine.anatomical_structure Oncology Immunology Leukocyte Common Antigens |
| Zdroj: | Leukemia Research. 17:209-216 |
| ISSN: | 0145-2126 |
| DOI: | 10.1016/0145-2126(93)90003-4 |
| Popis: | CD45 isoform expression was studied in 204 cases of B-cell lymphoproliferative disease, including 162 chronic lymphocytic leukaemia (CLL). In almost half the samples tested, CD45R0 was co-expressed with CD45RA, unlike normal B-cells, which express only CD45RA, except at terminal stages of differentiation. In a small number of cases CD45R0 was the dominant isoform expressed. No correlation could be discerned either with Binet or RAI staging in CLL or with disease type CLL, prolymphocytic leukaemia (PLL) or hairy cell leukaemia (HCL). Comparison of CD45 isoform expression with other markers showed no correlation with apparent maturational status of the cells involved. |
| Databáze: | OpenAIRE |
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