Molecular Modeling of the Neurohypophyseal Receptor/Atosiban Complexes
| Autor: | Magdalena J, Slusarz, Rafał, Slusarz, Rajmund, Kaźmierkiewicz, Jerzy, Trojnar, Kazimierz, Wisniewski, Jerzy, Ciarkowski |
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| Rok vydání: | 2003 |
| Předmět: |
Models
Molecular Receptors Vasopressin medicine.medical_specialty Vasopressin Protein Conformation Uterotonic Biochemistry Oxytocin Antagonist Hormone Antagonists Vasotocin Structural Biology Internal medicine medicine Humans Computer Simulation Amino Acids Receptor Binding Sites Chemistry Atosiban General Medicine Endocrinology Oxytocin Receptors Oxytocin Docking (molecular) hormones hormone substitutes and hormone antagonists Hormone medicine.drug |
| Zdroj: | Protein & Peptide Letters. 10:295-302 |
| ISSN: | 0929-8665 |
| Popis: | The neurohypophyseal nonapeptide hormone oxytocin (OT) is the strongest uterotonic substance known and is responsible for the initiation of labor. Conversely, oxytocin antagonists blocking uterine OT receptor can suppress uterus contraction. In this paper we describe a computer simulated docking pertinent to affinity of an oxytocin antagonist atosiban towards OT receptor, versus vasopressin V1a and V2 receptors. |
| Databáze: | OpenAIRE |
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