The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags

Autor: Helena, Brentani, Otávia L, Caballero, Anamaria A, Camargo, Aline M, da Silva, Wilson Araújo, da Silva, Emmanuel, Dias Neto, Marco, Grivet, Arthur, Gruber, Pedro Edson Moreira, Guimaraes, Winston, Hide, Christian, Iseli, C Victor, Jongeneel, Janet, Kelso, Maria Aparecida, Nagai, Elida Paula Benquique, Ojopi, Elisson C, Osorio, Eduardo M R, Reis, Gregory J, Riggins, Andrew John George, Simpson, Sandro, de Souza, Brian J, Stevenson, Robert L, Strausberg, Eloiza H, Tajara, Sergio, Verjovski-Almeida, Marcio Luis, Acencio, Mário Henrique, Bengtson, Fabiana, Bettoni, Walter F, Bodmer, Marcelo R S, Briones, Luiz Paulo, Camargo, Webster, Cavenee, Janete M, Cerutti, Luis Eduardo, Coelho Andrade, Paulo César, Costa dos Santos, Maria Cristina, Ramos Costa, Israel Tojal, da Silva, Marcos Roberto H, Estécio, Karine, Sa Ferreira, Frank B, Furnari, Milton, Faria, Pedro A F, Galante, Gustavo S, Guimaraes, Adriano Jesus, Holanda, Edna Teruko, Kimura, Maarten R, Leerkes, Xin, Lu, Rui M B, Maciel, Elizabeth A L, Martins, Katlin Brauer, Massirer, Analy S A, Melo, Carlos Alberto, Mestriner, Elisabete Cristina, Miracca, Leandro Lorenco, Miranda, Francisco G, Nobrega, Paulo S, Oliveira, Apua C M, Paquola, José Rodrigo C, Pandolfi, Maria Ines de Moura, Campos Pardini, Fabio, Passetti, John, Quackenbush, Beatriz, Schnabel, Mari Cleide, Sogayar, Jorge E, Souza, Sandro R, Valentini, Andre C, Zaiats, Elisabete Jorge, Amaral, Liliane A T, Arnaldi, Amelia Goes, de Araújo, Simone Aparecida, de Bessa, David C, Bicknell, Maria Eugenia, Ribeiro de Camaro, Dirce Maria, Carraro, Helaine, Carrer, Alex F, Carvalho, Christian, Colin, Fernando, Costa, Cyntia, Curcio, Ismael Dale Cotrim, Guerreiro da Silva, Neusa, Pereira da Silva, Márcia, Dellamano, Hamza, El-Dorry, Enilza Maria, Espreafico, Ari José, Scattone Ferreira, Cristiane, Ayres Ferreira, Maria Angela H Z, Fortes, Angelita Habr, Gama, Daniel, Giannella-Neto, Maria Lúcia C C, Giannella, Ricardo R, Giorgi, Gustavo Henrique, Goldman, Maria Helena S, Goldman, Christine, Hackel, Paulo Lee, Ho, Elza Myiuki, Kimura, Luiz Paulo, Kowalski, Jose E, Krieger, Luciana C C, Leite, Ademar, Lopes, Ana Mercedes S C, Luna, Alan, Mackay, Suely Kazue Nagahashi, Mari, Adriana Aparecida, Marques, Waleska K, Martins, André, Montagnini, Mario, Mourão Neto, Ana Lucia T O, Nascimento, A Munro, Neville, Marina P, Nobrega, Mike J, O'Hare, Audrey Yumi, Otsuka, Anna Izabel, Ruas de Melo, Maria Luisa, Paco-Larson, Gonçalo, Guimarães Pereira, Joao Bosco, Pesquero, Juliana Gilbert, Pessoa, Paula, Rahal, Claudia Aparecida, Rainho, Vanderlei, Rodrigues, Silvia Regina, Rogatto, Camila Malta, Romano, Janaina Gusmao, Romeiro, Benedito Mauro, Rossi, Monica, Rusticci, Renata, Guerra de Sá, Simone Cristina, Sant' Anna, Miriam L, Sarmazo, Teresa Cristina de Lima E, Silva, Fernando Augusto, Soares, Maria de Fátima, Sonati, Josane, de Freitas Sousa, Diana, Queiroz, Valéria, Valente, André Luiz, Vettore, Fabiola Elizabeth, Villanova, Marco Antonio, Zago, Heloisa, Zalcberg
Rok vydání: 2003
Předmět:
Zdroj: Proceedings of the National Academy of Sciences of the United States of America. 100(23)
ISSN: 0027-8424
Popis: Whereas genome sequencing defines the genetic potential of an organism, transcript sequencing defines the utilization of this potential and links the genome with most areas of biology. To exploit the information within the human genome in the fight against cancer, we have deposited some two million expressed sequence tags (ESTs) from human tumors and their corresponding normal tissues in the public databases. The data currently define ≈23,500 genes, of which only ≈1,250 are still represented only by ESTs. Examination of the EST coverage of known cancer-related (CR) genes reveals that
Databáze: OpenAIRE