Effect of estrogen replacement therapy on hepatic triglyceride lipase, lipoprotein lipase and lipids including apolipoprotein E in climacteric and elderly women
| Autor: | Kenichi Hosokawa, Takara Yamamoto, Hideo Honjo, Tomohiro Kashiwagi, Kazuaki Yokota, Tomoharu Okubo, Koichi Iwasa, Mamoru Urabe, Noriko Kikuchi, Hiroshi Tsuchiya |
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| Rok vydání: | 1996 |
| Předmět: |
Apolipoprotein E
Adult medicine.medical_specialty Very low-density lipoprotein Apolipoprotein B Endocrinology Diabetes and Metabolism Blood lipids Apolipoproteins E Endocrinology Internal medicine medicine Humans Aged Climacteric Lipoprotein lipase biology business.industry Estrogen Replacement Therapy nutritional and metabolic diseases Lipase Middle Aged Lipids Postmenopause Lipoprotein Lipase Liver Premenopause biology.protein lipids (amino acids peptides and proteins) Female Apolipoprotein C2 business Lipoprotein |
| Zdroj: | Endocrine journal. 43(6) |
| ISSN: | 0918-8959 |
| Popis: | Estrogen provides beneficial effects on hyperlipidemia in climacteric and elderly women. In this study of 68 women (37 to 67 years old), hepatic triglyceride lipase (HTGL), lipoprotein lipase (LpL) serum lipids and apolipoproteins were analyzed to investigate the effects of estrogen replacement therapy (ERT). After menopause, LpL, total cholesterol, low-density lipoprotein (LDL)-cholesterol, and apolipoprotein B increased. But ERT suppressed total cholesterol, LDL-cholesterol, apolipoprotein B, and especially apolipoprotein E in menopausal women. The mechanism was thought that ERT significantly suppressed HTGL, but LpL was not affected. Estrogen also increases hepatic LDL receptors and accelerates transfer of serum LDL-C (and TC). It was said that HTGL accelerates conversion of intermediate-density lipoprotein (IDL) to LDL. The suppression of HTGL by the ERT may decrease conversion of IDL to LDL and lower LDL-C (and TC). These estrogen's beneficial effects on lipids, may prevent the atherosclerosis. In addition, apolipoprotein E increases senile plaques in senile dementia-Alzheimer's type. The decrease in apolipoprotein E with ERT may be related to cognitive functions of elderly women. |
| Databáze: | OpenAIRE |
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