The Effect of Steroid Treatment with Inhaled Budesonide or Intravenous Methylprednisolone on Phosgene-Induced Acute Lung Injury in a Porcine Model
| Autor: | Charles Masey, R. F. R. Brown, John Jenner, Thomas Mann, Adam N. Smith, Paul Rice, BJ Jugg, Janet Platt |
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| Rok vydání: | 2009 |
| Předmět: |
Budesonide
Swine medicine.medical_treatment Acute Lung Injury Lung injury Bronchoalveolar Lavage Methylprednisolone Intermittent Positive-Pressure Ventilation Random Allocation chemistry.chemical_compound Administration Inhalation medicine Animals Chemical Warfare Agents Phosgene Antidote Saline Inhalation exposure Intravenous methylprednisolone business.industry Public Health Environmental and Occupational Health General Medicine chemistry Area Under Curve Anesthesia Injections Intravenous Female Inflammation Mediators business medicine.drug |
| Zdroj: | Military Medicine. 174:1287-1294 |
| ISSN: | 1930-613X 0026-4075 |
| DOI: | 10.7205/milmed-d-09-00050 |
| Popis: | Toxic industrial chemicals e.g., phosgene, are widely used as reactive intermediates in industrial processes. Inhalation exposure to these chemicals can result in life-threatening acute lung injury (ALI), to which no specific antidote exists. This study aimed to assess the potential benefit of steroids in treating phosgene induced ALI. Anesthetized pigs were instrumented, exposed to phosgene Ct 2000 mg.min.m(-3) (Ct is the product of concentration [mg.m(-3)] x time [min]), and ventilated with intermittent positive pressure ventilation before being randomized to study part 1: treatment with intravenous glucose saline (20 mL) or methylprednisolone (12.5 mg.kg(-1) in 20 mL) 6 h postexposure or study part 2: treatment with inhaled glucose saline (2 mL) or budesonide (2 mL of 0.5 mg.mL(-1) solution) at 1, 6, 12, and 18 h postexposure. Biochemical parameters and animal physiology were monitored to 24 h postexposure. The results show no change in mortality, lung edema, or shunt fraction; however, some beneficial effects on cardiac parameters e.g., stroke volume, left ventricular stroke work, were noted. Steroids were neither beneficial nor detrimental in the treatment of phosgene induced ALI. This study does not support the use of steroids alone as a treatment, but their use in a combined therapy strategy should be investigated. |
| Databáze: | OpenAIRE |
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