Relapsing Tumefactive Demyelination: A Case Report
| Autor: | Nurija Bilalovic, Maida Nikšić, Almir Džurlić, Enra Suljic, Ibrahim Omerhodžić, Dino Lisica, Nevena Mahmutbegović |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Multiple Sclerosis Adolescent Polyradiculoneuropathy Central Nervous System Neoplasms Diagnosis Differential Lesion Recurrence Tumefactive demyelination Biopsy medicine Gemistocytic Astrocytoma Demyelinating disease Humans medicine.diagnostic_test business.industry Multiple sclerosis General Medicine medicine.disease Magnetic Resonance Imaging Fresh frozen Female Radiology medicine.symptom Differential diagnosis business Demyelinating Diseases |
| Zdroj: | Acta Medica Academica. 47:193 |
| ISSN: | 1840-2879 1840-1848 |
| DOI: | 10.5644/ama2006-124.231 |
| Popis: | Objective. We present a case of relapsing tumefactive demyelination in a young female patient, that posed a real diagnostic challenge, with a heterogeneous clinical picture, atypical for multiple sclerosis (MS) presentation, and neuroradiological manifestations with a high suspicion of neoplastic diseases.Case Report. An 18-year old female patient presented to our Neurosurgical Out-patients’ Clinic with symptoms atypical for multiple sclerosis, unremarkable neurological deficit, one tumefactive lesion on MRI, followed by relapse and another two lesions within a period of six months. We decided to perform biopsy of the tumefactive lesion with compressive effect. Serological and clinical data were negative for MS, and the patient did not respond well to corticosteroid therapy. Fresh frozen tumor tissue aroused a strong suspicion of gemistocytic astrocytoma, so total resection was done, but the definitive pathohistological examination confirmed tumefactive demyelination.Conclusion. For clinicians, it is important to consider demyelinating disease in the differential diagnosis of a tumorlike lesion of the central nervous system, in order to avoid invasive and potentially harmful diagnostic procedures, especially in younger patients. |
| Databáze: | OpenAIRE |
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