Cell-mediated immune responses to GAD and β-casein in type 1 diabetes mellitus in Thailand

Autor: Sutin Sriussadaporn, Thawatchai Pasurakul, Pa-thai Yenchitsomanus, Tararaj Dharakul, Sathit Vannasaeng, Ploybutr S, Chaicharn Deerochanawong, Napatawn Banchuin, Watip Boonyasrisawat
Rok vydání: 2002
Předmět:
Zdroj: Diabetes Research and Clinical Practice. 55:237-245
ISSN: 0168-8227
DOI: 10.1016/s0168-8227(01)00322-9
Popis: We measured the cell-mediated immune response to GAD and bovine beta-casein in 38 type 1 and 37 type 2 diabetic patients who visited diabetic clinics or who were hospitalized in Bangkok, Thailand, and in 43 normal controls, by using a lymphoproliferation assay. Positive results against GAD were found in 29/38 (76.3%) type 1, 6/37 (16.2%) type 2 diabetic patients and 1/43 (2.3%) normal controls. Positive results against bovine beta-casein were found in 18/38 (47.4%), 5/37 (13.5%) and 1/43 (2.3%) of these subjects, respectively. The frequencies of the positive results and the magnitude of the responses to both antigens in type 1 diabetic patients were significantly higher than those in the other two groups (P0.001). In addition, the prevalence of a positive lymphoproliferative response to these antigens in type 1 diabetic patients was higher than that of anti-GAD antibody positivity in the same group of subjects (26.3%). Thus, the prevalence of positive lymphoproliferative response to GAD in type 1 diabetic patients studied was higher than the prevalence of other autoimmune markers previously reported in type 1 diabetic patients in Thailand.
Databáze: OpenAIRE
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