Prevalence of Mycoplasma pneumoniae Infection in Malagasy Children

Autor: Lova Ravelomanana, Nadjet Benhaddou, André Zo Andrianirina, Naïm Bouazza, Patrick Imbert, Annick Lalaina Robinson, Mbola Rakotomahefa, Josette Raymond, Frédérique Randrianirina, Rabezanahary Andriamihaja, Elisoa Ratsima, Honoré Raobidjaona
Přispěvatelé: CHU d’Antananarivo, CHU Cochin [AP-HP], Université Paris Descartes - Paris 5 (UPD5), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Hôpital Joseph Raseta Befelatanana, Institut Pasteur de Madagascar, Réseau International des Instituts Pasteur (RIIP), Association Jeremi Rhônes-Alpes (JEREMI RA), Hôpital d'Instruction des Armées Begin, Service de Santé des Armées, Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
Rok vydání: 2017
Předmět:
Male
Mycoplasma pneumoniae
MESH: Asthma
medicine.disease_cause
Serology
MESH: Madagascar
0302 clinical medicine
MESH: Child
MESH: Antibodies
Bacterial
Prevalence
Medicine
030212 general & internal medicine
Prospective Studies
Prospective cohort study
Child
MESH: Developing Countries
MESH: Immunoglobulin G
MESH: Case-Control Studies
Antibodies
Bacterial
MESH: Immunoglobulin M
3. Good health
Anti-Bacterial Agents
Community-Acquired Infections
Infectious Diseases
C-Reactive Protein
MESH: Community-Acquired Infections
Child
Preschool
MESH: Mycoplasma pneumoniae
Female
Microbiology (medical)
medicine.medical_specialty
Adolescent
MESH: Social Class
03 medical and health sciences
Internal medicine
MESH: Anti-Bacterial Agents
Streptococcus pneumoniae
MESH: C-Reactive Protein
Pneumonia
Mycoplasma
Madagascar
Humans
Developing Countries
MESH: Prevalence
Asthma
MESH: Adolescent
[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics
MESH: Humans
MESH: Pneumonia
Mycoplasma
business.industry
MESH: Child
Preschool
Case-control study
Odds ratio
medicine.disease
MESH: Male
MESH: Prospective Studies
respiratory tract diseases
Pneumonia
030228 respiratory system
Immunoglobulin M
Social Class
Case-Control Studies
Immunoglobulin G
Pediatrics
Perinatology and Child Health
Immunology
business
MESH: Female
Zdroj: Pediatric Infectious Disease Journal
Pediatric Infectious Disease Journal, Lippincott, Williams & Wilkins, 2017, 36 (5), pp.467-471. ⟨10.1097/INF.0000000000001471⟩
ISSN: 1532-0987
0891-3668
DOI: 10.1097/INF.0000000000001471⟩
Popis: International audience; BACKGROUND:Childhood community-acquired pneumonia is a leading cause of childhood morbidity in low-income countries. The etiologic agents are usually Staphylococcus aureus, Streptococcus pneumoniae and Mycoplasma pneumoniae. M. pneumoniae was recognized as a cofactor in asthmatic disease. High asthma prevalence was reported in Madagascar. Our aim was to clarify the prevalence of M. pneumoniae infection in this country and its relationship with asthma.METHODS:A prospective study was conducted in 351 children (from 2 to 16 years of age) from January 2012 to December 2014. According to the clinical symptoms, children were enrolled in 3 groups: "control group" (CG, n = 106), "asthma group" (n = 129) and "pneumonia group" (n = 116). The IgG and IgM M. pneumoniae status was evaluated by an enzyme-linked immunosorbent assay. Clinical signs of infection, socioeconomic data and antimicrobial treatment were recorded.RESULTS:The overall prevalence of M. pneumoniae infection was 18.2%. The multivariate analysis demonstrated that M. pneumoniae infection was significantly more frequent in the CG [pneumonia group vs. CG: odds ratio = 0.45 (0.21-0.91), P = 0.037 and asthma group vs. CG: odds ratio = 0.39 (0.18-0.87), P = 0.021]. The C-reactive protein value was significantly higher in children with M. pneumonia-positive serology (85 vs. 61 mg/L, P = 0.03). Of note, 99 (41%) children received antibiotics before attending.CONCLUSIONS:We report a prevalence of 18.2% for M. pneumoniae infection in children in Madagascar. The prevalence of M. pneumoniae infection was higher in the control patients than in asthmatic ones.
Databáze: OpenAIRE
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