| Autor: |
Taisuke Kuroda, Yohei Minamijima, Hiroshi Mita, Norihisa Tamura, Kentaro Fukuda, Atsutoshi Kuwano, Pierre‐Louis Toutain, Fumio Sato |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of veterinary pharmacology and therapeuticsREFERENCES. |
| ISSN: |
1365-2885 |
| Popis: |
A pharmacokinetics/pharmacodynamics (PK/PD) approach was used to determine the best empirical dosage regimen of cefazolin (CEZ) after intramuscular (IM) administration of CEZ in horses. Seven horses received a single IM or intravenous (IV) administration of CEZ of 5 mg/kg bodyweight (BW) according to a crossover design. CEZ plasma concentrations were measured using LC-MS/MS. The plasma concentrations in these seven horses and those of six other horses obtained in a previous study with an IV CEZ dose of 10 mg/kg were modelled simultaneously using NonLinear Mixed-Effect modelling followed by Monte Carlo simulations to establish a rational dosage regimen. A 90% Probability of Target Attainment (PTA) for a PK/PD target of a free plasma concentration exceeding MIC |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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