The relationship between the severity of disability and serum IL-8 in acute ischemic stroke patients

Autor: Mohammed M. Abbass, Lamiaa I. Daker, Hala A. Shaheen, Asmaa A. Abd El Fattah
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, Vol 54, Iss 1, Pp 1-5 (2018)
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
ISSN: 1687-8329
DOI: 10.1186/s41983-018-0025-z
Popis: Background Stroke is the third leading cause of death and leading cause of adult disability worldwide. Long-term disability is a significant problem among survivors; post-stroke inflammation is well known to contribute to the expansion of the ischemic lesion resulting in significant morbidity and disability. To study the impact of serum level of IL-8 on severity of disability in patients with acute ischemic stroke in the first 48 h post stroke. Methods A cross-sectional case control study was conducted on 44 patients with acute ischemic stroke (in the first 48 h). The patients were subjected to full neurological examination, computed tomography (CT) and magnetic resonance imaging (MRI) of the brain, and assessment of stroke disability using the National Institute of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS). Measurement of the serum levels of IL-8, erythrocyte sedimentation rate, and C-reactive protein (CRP) was done. Forty-four matched control subjects for their age and sex were included for comparison of serum level of IL-8. Results The level of IL-8 was significantly higher in the patients than in the control subjects (p
Databáze: OpenAIRE
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