Multisystemic eosinophilic epitheliotropic disease in a horse in Brazil
| Autor: | Cláudio João Mourão Laisse, Welden Panziera, Saulo Petinatti Pavarini, David Driemeier, Elizabeth Caldas Soares, Júlio César Westphalen, Lismara Castro do Nascimento, Luciana Sonne, Denise Bicca Fernandes |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Pathology
medicine.medical_specialty granuloma eosinofílico 040301 veterinary sciences Eosinofilia Connective tissue lcsh:Agriculture 0403 veterinary science equino Eosinophilic Eosinophilia medicine Granuloma eosinófilo Mesenteric lymph nodes histopatologia lcsh:Agriculture (General) Oral mucosa Equinos General Veterinary integumentary system business.industry lcsh:S 0402 animal and dairy science 04 agricultural and veterinary sciences lcsh:S1-972 040201 dairy & animal science horse Histopatologia medicine.anatomical_structure Giant cell Duodenum histopathology Animal Science and Zoology eosinophilic granuloma medicine.symptom business Agronomy and Crop Science Rare disease |
| Zdroj: | Ciência Rural v.47 n.5 2017 Ciência Rural Universidade Federal de Santa Maria (UFSM) instacron:UFSM Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS Ciência Rural, Volume: 47, Issue: 5, Article number: e20160896, Published: 02 MAY 2017 Ciência Rural, Vol 47, Iss 5 |
| Popis: | Equine multisystemic eosinophilic epitheliotropic disease (MEED) is a rare disease, characterized by eosinophilia and eosinophilic infiltration of several organs. A 5-year-old horse presented pruritus, areas of alopecia, and moderate eosinophilia. The horse was treated with corticosteroids and antibiotics without substantial improvement; and after the disease progressed to fever, diarrhea, gastric reflux and progressive weight loss. Due to poor prognosis the horse was euthanized. Necropsy revealed poor body condition, multiple to coalescing foci of alopecia, with epidermal ulcerations and crusts on the head and distal parts of the limbs. The proximal duodenum was enlarged, with 3 intraluminal nodules. Histopathological evaluation revealed eosinophilic granulomas in the skin, oral mucosa, duodenum, pancreas, and mesenteric lymph nodes, which were associated with infiltrates of eosinophils, lymphocytes, macrophages, multinucleated giant cells, and occasional plasma cells, along with fibrovascular connective tissue proliferation. MEED should be included in the differential diagnosis of horses with skin lesions concomitant with clinical signs of gastrointestinal illness. RESUMO: Doença multissistêmica eosinofílica epiteliotrópica (DMEE) dos equinos é uma doença rara que se caracteriza por eosinofilia e infiltrado de eosinófilos em vários órgãos. Um equino com cinco anos de idade apresentou prurido, áreas de alopecia e eosinofilia moderada. O equino foi tratado com corticosteroides e antibióticos sem melhora clínica significativa, com evolução para febre, diarreia, refluxo gástrico e emagrecimento progressivo. Devido ao prognóstico desfavorável, o equino foi eutanasiado. Na necropsia, apresentou condição corporal ruim, áreas multifocais a coalescentes de alopecia, ulceração da epiderme e crostas na cabeça e parte distal dos membros. A região proximal do duodeno estava aumentada de volume e apresentou três nódulos intraluminais. No exame histopatológico foram observados granulomas eosinofílicos associados a infiltrado de eosinófilos, linfócitos, macrófagos, células gigantes multinucleadas, ocasionais plasmócitos e proliferação de tecido conjuntivo fibroso na pele, mucosa oral, duodeno, pâncreas e linfonodos mesentéricos. DMEE deve ser considerada um diagnóstico diferencial em equinos que apresentem concomitantemente lesões cutâneas e sinais de doença gastrointestinal. |
| Databáze: | OpenAIRE |
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