| Autor: |
Jose L. Escobar, Javier V. Villalpando, Jose F. Barrera, Jose J. Becerra, David A. Delgado, Enrique Gómez-Álvarez, Federico Jiménez, Raúl Apresa, Vania Quisbert, Jorge L. Narváez, Gerardo Santana, Norma E. Cano, Maria R. Jaramillo, Juan M. González, Reynaldo J. Jiménez, Miguel A. Águila, José M. Castellano, Manuel Sanchez, Yolanda P. Rodriguez, Armando Zepeda, Mario Flores, Jorge Cedillo, Jose Sacen, Claudia C. Rojas, Marcelo Jiménez, Luis Gonzaga, Pedro Mejía, R. F. Silva, Jose L. Ubiarco, Ezequiel Gomez, Luis J. Garcia, Jorge A. Rodriguez, Delia Ruiz, Félix González, Juan A. Quintana, Víctor M. Hernández, Juan Martin, Maria R. Zarate, Alejandro Chávez, Alejandro Cortes, Javier Salinas, Jose A. Campos, Francisco Martinez, Miguel A. Guerrero, Ezequiel Garcia, Beatriz Mendoza, Silvia Rivera, Alejandro Rivas, Adriana L. Vega, Juan M. Arellano, Jose A. Maldonado, Jose A. Gaxiola, Enrique Gomez, Javier Estrada, Maria Teresa Colosia, Noé D. Monroy, Rubén O. Yza, Karla G. Wong, Fernando F. Garcia, Elias Rodriguez, Manuel Oropeza, Eliceo Gracia, Gloria Ledesma, Martin Limas, Juan J. Atilano, Valentin Fuster, Armando G. de la Cruz, Mariano D. Cervantes, Pedro Hernández, Miguel Marvaes, Enrique González, Jorge L. Flores, Jose J. Santos, Marco A. Rios, Eddie A. Favela, Guillermo A. Rodriguez, Jose A. Magaña, Gustavo Alarcón, Maria A. Rodriguez, Luis M. Fuentes, Omar Mejía, Jose C. Flores, Gabriela Borrayo, Maria L. Ramírez, Luis E. Lopez, Emilio Ruiz, Maria A. Asmida, Francisco Vera, Salvador Ocampo, Víctor M. Salas, Raúl Segura, Nancy Bello, Rafael Corral, Maria G. Jiménez, Octavio Beltrán, Maria T. Olac, Héctor V. Ballardo, Misael Arroyo, Marisela C. Parra, Rosalba Lara, Sonia Salgado, Angel Morales, Laura A. Aranda, Jesús M. Acosta, Lázaro Aguilar, Juan E. Becerril, Hilario Aguilar, Jose A. Castro, Jorge E. Hernández, Ulises Romero, Víctor Peña, Jose L. Diez, Francisco J. González, Nadia Álvarez, Simón Areola, Enrique A. Velázquez, Ana K. Villanueva, Víctor H. Báez, Alejandro Rodriguez, Miguel A. González, Armando Moreno, Ana L. Lerma, Isilio N. Morales, Javier Casian, Fernando González, Juan Verdejo, Alejandro Tirado, Ramon Flores, Enrique Morlet, Sergio Téllez, Bertha Vitela, Alejandro Javier García, Antonio Corona, Edith Mc. Vallarta, German R. Bautista, Rafael Elias, Maria I. Córdoba, Joel E. Padrón, Joaquín I. Moreno, Mario L. Rodriguez, Jose Pegueros, Susana Ibarra, Borja Ibanez, Marco Martinez Rios, Maria C. Guadalupe, Roberto Vázquez, Rafael Márquez, Mirtha Valenzuela |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Archives of Medical Research |
| ISSN: |
1873-5487 |
| Popis: |
The cardiovascular disease pandemic has promoted the cardiovascular polypill as one of the most scalable public health strategies to improve cardiovascular risk by increasing accessibility and adherence to treatments. Data from randomized clinical trials has shown that the polypill strategy significantly improves adherence as well as risk factor control (cholesterol and blood pressure), however, to date, no information from phase IV registries has been available.We conducted a multicentre, observational and prospective registry of a polypill-based treatment strategy. A total of 1193 patients in Mexico were included. Patient demographics, clinical history, blood pressure, analysis of blood lipids and the Framingham risk score were measured at baseline and after 12 months of treatment with the CNIC-Ferrer polypill.At one year with the polypill, systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels changed from mean 146.9 mmHg to 128 mmHg (p 0.001), and from 89.1 mmHg to 80.4 mmHg (p 0.001) respectively. LDLc levels were significantly reduced 132.5-107.6 mg/dL (p 0.001). The 10 year Framingham cardiovascular disease risk was also reduced in the high-risk group (33.7 + 22.0 vs. 21.2 + 14.8; p 0.001) and in the intermediate risk group (23.7 + 14.8 vs. 12.7 + 11.4; p 0.001).To our knowledge, the results of the current study constitute the first real life data on the impact of a polypill therapy on cardiovascular risk factor control. The results show major improvements on the primary outcome, above and beyond those presented previously in the setting of randomized clinical trials. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect 