Real-world homologous recombination repair mutation testing in metastatic castration-resistant prostate cancer in the USA, Europe and Japan

Autor:	Andrea Leith, Amanda Ribbands, Jeri Kim, Matthew Last, Sophie Barlow, Lingfeng Yang, Sameer R Ghate
Rok vydání:	2022
Předmět:	Male Cancer Research Recombinational DNA Repair General Medicine Middle Aged United States Europe Prostatic Neoplasms Castration-Resistant Japan Oncology Surveys and Questionnaires Mutation Biomarkers Tumor Humans Genetic Testing Neoplasm Metastasis Practice Patterns Physicians' Aged
Zdroj:	Future Oncology. 18:937-951
ISSN:	1744-8301 1479-6694
Popis:	Aim: To assess homologous recombination repair mutation (HRRm) testing patterns in metastatic castration-resistant prostate cancer. Methods: A point-in-time, international survey conducted January–August 2020. Results: Three-quarters of physicians (oncologists, urologists, specialist surgeons) globally reported access to genetic/genomic testing and just over half were HRRm testers. Surveyed physicians reported HRRm testing and positivity rates for 1913 patients, which were 18.1% and 33.7%, respectively. Of patients tested (n = 347), the most common HRR genes tested were BRCA (91.6%) and ATM (47.3%). Conclusion: Overall testing rates were low, with physicians mostly testing patients they considered higher risk. Increased awareness and education are needed to encourage broader testing, to understand familial risk and to identify patients with worse outcomes or those eligible for life-prolonging treatments.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc6e3bc062747961acd4f5787b1477cb https://doi.org/10.2217/fon-2021-1113 Zobrazit plný text záznamu